Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2145962..2146225 Replicon chromosome
Accession NZ_CP035101
Organism Staphylococcus aureus strain ATCC 12600

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag EQG65_RS10865 Protein ID WP_001802298.1
Coordinates 2146121..2146225 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2145962..2146126 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQG65_RS10845 2142145..2142810 - 666 WP_001024094.1 SDR family oxidoreductase -
EQG65_RS10850 2142962..2143282 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
EQG65_RS10855 2143284..2144264 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
EQG65_RS10860 2144530..2145621 + 1092 WP_000495671.1 lytic regulatory protein -
- 2145962..2146126 + 165 - - Antitoxin
EQG65_RS10865 2146121..2146225 - 105 WP_001802298.1 hypothetical protein Toxin
EQG65_RS10870 2146386..2146869 - 484 Protein_2048 recombinase family protein -
EQG65_RS10875 2146912..2148048 - 1137 WP_000115562.1 SAP domain-containing protein -
EQG65_RS10880 2148337..2148429 + 93 WP_001790138.1 hypothetical protein -
EQG65_RS10885 2149134..2149991 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
EQG65_RS10890 2150059..2150841 - 783 WP_000908177.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T117196 WP_001802298.1 NZ_CP035101:c2146225-2146121 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T117196 NZ_CP035101:c2146225-2146121 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT117196 NZ_CP035101:2145962-2146126 [Staphylococcus aureus]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References