117190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 854401..854824 Replicon chromosome
Accession NZ_CP035101
Organism Staphylococcus aureus strain ATCC 12600

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EQG65_RS04285 Protein ID WP_001836226.1
Coordinates 854401..854652 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EQG65_RS04290 Protein ID WP_000028421.1
Coordinates 854642..854824 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQG65_RS14155 849954..850103 + 150 WP_001081076.1 hypothetical protein -
EQG65_RS04230 850096..850377 - 282 WP_000414755.1 hypothetical protein -
EQG65_RS04235 850443..851213 + 771 WP_001836222.1 conserved phage C-terminal domain-containing protein -
EQG65_RS04240 851223..852002 + 780 WP_000803062.1 ATP-binding protein -
EQG65_RS04245 851996..852154 + 159 WP_000256589.1 hypothetical protein -
EQG65_RS04250 852167..852388 + 222 WP_001123695.1 DUF3269 family protein -
EQG65_RS04255 852398..852802 + 405 WP_001836225.1 DUF1064 domain-containing protein -
EQG65_RS04260 852807..852992 + 186 WP_001187243.1 DUF3113 family protein -
EQG65_RS04265 852993..853298 + 306 WP_000101252.1 hypothetical protein -
EQG65_RS04270 853426..853782 + 357 WP_000029376.1 hypothetical protein -
EQG65_RS04275 853786..854028 + 243 WP_001562543.1 phage protein -
EQG65_RS04280 854037..854408 + 372 WP_001557190.1 hypothetical protein -
EQG65_RS04285 854401..854652 + 252 WP_001836226.1 DUF1024 family protein Toxin
EQG65_RS04290 854642..854824 + 183 WP_000028421.1 hypothetical protein Antitoxin
EQG65_RS04295 854817..855347 + 531 WP_000185651.1 dUTP pyrophosphatase -
EQG65_RS04300 855384..855590 + 207 WP_000195785.1 DUF1381 domain-containing protein -
EQG65_RS04305 855587..855781 + 195 WP_000132920.1 hypothetical protein -
EQG65_RS04310 855778..855981 + 204 WP_001072794.1 hypothetical protein -
EQG65_RS04315 855974..856147 + 174 WP_001657250.1 transcriptional activator RinB -
EQG65_RS04320 856148..856294 + 147 WP_000990005.1 hypothetical protein -
EQG65_RS04325 856318..856740 + 423 WP_000162701.1 RinA family phage transcriptional activator -
EQG65_RS04330 856928..857422 + 495 WP_001038244.1 terminase small subunit -
EQG65_RS04335 857425..858720 + 1296 WP_000273011.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 839167..884244 45077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9457.35 Da        Isoelectric Point: 3.8049

>T117190 WP_001836226.1 NZ_CP035101:854401-854652 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T117190 NZ_CP035101:854401-854652 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6683.59 Da        Isoelectric Point: 4.3791

>AT117190 WP_000028421.1 NZ_CP035101:854642-854824 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Download         Length: 183 bp

>AT117190 NZ_CP035101:854642-854824 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References