Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 26228..26886 | Replicon | plasmid p74.1Kbp |
Accession | NZ_CP035047 | ||
Organism | Acinetobacter baumannii strain ABUH793 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | EP560_RS19760 | Protein ID | WP_000312250.1 |
Coordinates | 26527..26886 (-) | Length | 120 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | EP560_RS19755 | Protein ID | WP_001096429.1 |
Coordinates | 26228..26527 (-) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EP560_RS19710 | 22080..22532 | + | 453 | Protein_31 | hypothetical protein | - |
EP560_RS19715 | 22637..22894 | + | 258 | WP_000834290.1 | hypothetical protein | - |
EP560_RS19720 | 22899..23471 | + | 573 | WP_000443897.1 | hypothetical protein | - |
EP560_RS19725 | 23447..23626 | + | 180 | WP_000387630.1 | hypothetical protein | - |
EP560_RS19730 | 23643..24272 | + | 630 | WP_000701004.1 | hypothetical protein | - |
EP560_RS19735 | 24312..24530 | + | 219 | WP_001043201.1 | hypothetical protein | - |
EP560_RS19740 | 24550..25104 | + | 555 | WP_000790084.1 | hypothetical protein | - |
EP560_RS19745 | 25154..25690 | + | 537 | WP_000731978.1 | hypothetical protein | - |
EP560_RS19755 | 26228..26527 | - | 300 | WP_001096429.1 | helix-turn-helix transcriptional regulator | Antitoxin |
EP560_RS19760 | 26527..26886 | - | 360 | WP_000312250.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EP560_RS19765 | 27087..27653 | + | 567 | WP_000710385.1 | hypothetical protein | - |
EP560_RS19770 | 27702..27884 | + | 183 | WP_000373385.1 | hypothetical protein | - |
EP560_RS19775 | 27951..28649 | + | 699 | WP_000873188.1 | hypothetical protein | - |
EP560_RS19780 | 28788..29171 | + | 384 | WP_000654348.1 | hypothetical protein | - |
EP560_RS19785 | 29238..29996 | + | 759 | WP_001053127.1 | hypothetical protein | - |
EP560_RS19795 | 31051..31365 | + | 315 | WP_000708714.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaOXA-23 / aph(3')-VIa | - | 1..74091 | 74091 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 120 a.a. Molecular weight: 13751.62 Da Isoelectric Point: 4.8212
>T117167 WP_000312250.1 NZ_CP035047:c26886-26527 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK
Download Length: 360 bp
>T117167 NZ_CP035047:c26886-26527 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11012.93 Da Isoelectric Point: 10.4856
>AT117167 WP_001096429.1 NZ_CP035047:c26527-26228 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI
Download Length: 300 bp
>AT117167 NZ_CP035047:c26527-26228 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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