Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 26228..26886 Replicon plasmid p74.1Kbp
Accession NZ_CP035047
Organism Acinetobacter baumannii strain ABUH793

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EP560_RS19760 Protein ID WP_000312250.1
Coordinates 26527..26886 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EP560_RS19755 Protein ID WP_001096429.1
Coordinates 26228..26527 (-) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP560_RS19710 22080..22532 + 453 Protein_31 hypothetical protein -
EP560_RS19715 22637..22894 + 258 WP_000834290.1 hypothetical protein -
EP560_RS19720 22899..23471 + 573 WP_000443897.1 hypothetical protein -
EP560_RS19725 23447..23626 + 180 WP_000387630.1 hypothetical protein -
EP560_RS19730 23643..24272 + 630 WP_000701004.1 hypothetical protein -
EP560_RS19735 24312..24530 + 219 WP_001043201.1 hypothetical protein -
EP560_RS19740 24550..25104 + 555 WP_000790084.1 hypothetical protein -
EP560_RS19745 25154..25690 + 537 WP_000731978.1 hypothetical protein -
EP560_RS19755 26228..26527 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
EP560_RS19760 26527..26886 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EP560_RS19765 27087..27653 + 567 WP_000710385.1 hypothetical protein -
EP560_RS19770 27702..27884 + 183 WP_000373385.1 hypothetical protein -
EP560_RS19775 27951..28649 + 699 WP_000873188.1 hypothetical protein -
EP560_RS19780 28788..29171 + 384 WP_000654348.1 hypothetical protein -
EP560_RS19785 29238..29996 + 759 WP_001053127.1 hypothetical protein -
EP560_RS19795 31051..31365 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 / aph(3')-VIa - 1..74091 74091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-109)

Antitoxin

(12-88)


Sequences


Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T117167 WP_000312250.1 NZ_CP035047:c26886-26527 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T117167 NZ_CP035047:c26886-26527 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT117167 WP_001096429.1 NZ_CP035047:c26527-26228 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT117167 NZ_CP035047:c26527-26228 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References