Detailed information of TA system TA117160

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4137841..4138496
• Replicon: chromosome
• Accession: NZ_CP035042
• Organism: Halomonas sp. BC-M4-5

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EKK97_RS19215
• Protein ID: WP_159554384.1
• Coordinates: 4137841..4138179 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EKK97_RS19220
• Protein ID: WP_201296930.1
• Coordinates: 4138176..4138496 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKK97_RS19185	4133434..4133835	-	402	WP_159554376.1	SgcJ/EcaC family oxidoreductase	-
EKK97_RS19190	4134243..4134572	-	330	WP_159554378.1	hypothetical protein	-
EKK97_RS23980	4134789..4135106	-	318	WP_201296929.1	hypothetical protein	-
EKK97_RS19200	4135497..4136243	+	747	WP_201297147.1	ion transporter	-
EKK97_RS19205	4136262..4137524	+	1263	WP_159554382.1	DUF4236 domain-containing protein	-
EKK97_RS19215	4137841..4138179	+	339	WP_159554384.1	toxin	Toxin
EKK97_RS19220	4138176..4138496	+	321	WP_201296930.1	transcriptional regulator	Antitoxin
EKK97_RS19225	4138509..4139375	-	867	WP_159554388.1	hypothetical protein	-
EKK97_RS19230	4139448..4140461	-	1014	WP_201296931.1	sensor domain-containing diguanylate cyclase	-
EKK97_RS19235	4140688..4141329	+	642	WP_159554390.1	DsbA family oxidoreductase	-
EKK97_RS19240	4141512..4141916	-	405	WP_159554392.1	GFA family protein	-
EKK97_RS19245	4142060..4142371	-	312	WP_159554394.1	hypothetical protein	-
EKK97_RS19250	4142368..4143099	-	732	WP_201296932.1	AzlC family ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-102)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13018.81 Da
• Isoelectric Point: 10.4460

>T117160 WP_159554384.1 NZ_CP035042:4137841-4138179 [Halomonas sp. BC-M4-5]
MKAIFVELPPFERHRSTYFDDAAFRAFQNFLLQNPGAGDVIQGTGGLRKVRFSDPKRQKGKRGGVRIIYYWWLGGSQFWL
FTLYDKDSQDDLTTAQRKTLRQLLDAEINART

Nucleotide

• Length: 339 bp

>T117160 NZ_CP035042:4137841-4138179 [Halomonas sp. BC-M4-5]
ATGAAAGCCATATTTGTCGAGCTGCCACCCTTCGAGCGGCACCGTTCCACCTACTTCGATGACGCCGCCTTTCGTGCCTT
CCAGAATTTCTTGCTTCAGAACCCTGGGGCCGGTGACGTCATCCAAGGAACAGGCGGGCTGCGCAAGGTCCGGTTCAGTG
ATCCCAAGCGGCAGAAGGGAAAGCGGGGCGGTGTTCGCATCATTTACTACTGGTGGCTGGGAGGCTCCCAGTTCTGGCTG
TTCACCCTGTACGACAAGGATTCACAGGATGACCTCACGACAGCCCAGCGCAAGACCCTGAGACAGCTGCTGGATGCGGA
AATCAACGCGAGGACATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12258.02 Da
• Isoelectric Point: 6.0894

>AT117160 WP_201296930.1 NZ_CP035042:4138176-4138496 [Halomonas sp. BC-M4-5]
MTMGRNIFDELIEGFDALADERHGKRTLRSHSVELAEVPDVTASELIELRERLHMSRPVFAMYLRTNPRTLENWEQGRAK
PNAQAMTLIRLVQKYPETLEHLADLA

Nucleotide

• Length: 321 bp

>AT117160 NZ_CP035042:4138176-4138496 [Halomonas sp. BC-M4-5]
ATGACCATGGGCCGTAACATTTTTGATGAACTCATCGAGGGCTTCGATGCATTGGCAGATGAGCGCCATGGCAAGCGCAC
GCTACGCTCCCACTCCGTAGAGCTGGCAGAGGTTCCCGACGTCACAGCCAGCGAGCTCATCGAGCTGCGGGAGCGGCTGC
ATATGTCCCGCCCGGTTTTCGCCATGTACCTCCGCACCAACCCAAGGACGCTGGAGAATTGGGAGCAAGGCCGCGCCAAG
CCCAATGCCCAGGCCATGACACTCATCCGGCTGGTCCAGAAGTATCCTGAAACCCTCGAGCATCTCGCTGATCTTGCCTA
G