Detailed information of TA system TA117127

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 109978..110257
• Replicon: chromosome
• Accession: NZ_CP035005
• Organism: Staphylococcus aureus strain PCFH-226

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: EMO94_RS00620
• Protein ID: WP_001802298.1
• Coordinates: 109978..110082 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	110078..110257 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EMO94_RS00585	105877..106485	+	609	WP_000101714.1	TIR domain-containing protein	-
EMO94_RS00590	106775..107557	+	783	WP_000908191.1	ABC transporter ATP-binding protein	-
EMO94_RS00595	107625..108482	+	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
EMO94_RS00600	108612..108704	-	93	WP_000220902.1	hypothetical protein	-
EMO94_RS00605	109140..109298	-	159	WP_001792784.1	hypothetical protein	-
EMO94_RS00620	109978..110082	+	105	WP_001802298.1	hypothetical protein	Toxin
-	110078..110257	-	180	-	-	Antitoxin
EMO94_RS00625	110514..111605	-	1092	WP_000495673.1	hypothetical protein	-
EMO94_RS00630	111871..112851	-	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
EMO94_RS00635	112853..113173	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
EMO94_RS00640	113325..113990	+	666	WP_001024099.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T117127 WP_001802298.1 NZ_CP035005:109978-110082 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T117127 NZ_CP035005:109978-110082 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT117127 NZ_CP035005:c110257-110078 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin