117126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 109978..110241 Replicon chromosome
Accession NZ_CP035005
Organism Staphylococcus aureus strain PCFH-226

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag EMO94_RS00620 Protein ID WP_001802298.1
Coordinates 109978..110082 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 110077..110241 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EMO94_RS00585 105877..106485 + 609 WP_000101714.1 TIR domain-containing protein -
EMO94_RS00590 106775..107557 + 783 WP_000908191.1 ABC transporter ATP-binding protein -
EMO94_RS00595 107625..108482 + 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
EMO94_RS00600 108612..108704 - 93 WP_000220902.1 hypothetical protein -
EMO94_RS00605 109140..109298 - 159 WP_001792784.1 hypothetical protein -
EMO94_RS00620 109978..110082 + 105 WP_001802298.1 hypothetical protein Toxin
- 110077..110241 - 165 - - Antitoxin
EMO94_RS00625 110514..111605 - 1092 WP_000495673.1 hypothetical protein -
EMO94_RS00630 111871..112851 - 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
EMO94_RS00635 112853..113173 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
EMO94_RS00640 113325..113990 + 666 WP_001024099.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T117126 WP_001802298.1 NZ_CP035005:109978-110082 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T117126 NZ_CP035005:109978-110082 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT117126 NZ_CP035005:c110241-110077 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References