Detailed information of TA system TA117122

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 977619..977817
• Replicon: chromosome
• Accession: NZ_CP035003
• Organism: Staphylococcus aureus strain PCFA-221

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: EMO93_RS04940
• Protein ID: WP_001802298.1
• Coordinates: 977713..977817 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	977619..977657 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EMO93_RS04920	973805..974470	-	666	WP_001024099.1	SDR family oxidoreductase	-
EMO93_RS04925	974622..974942	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
EMO93_RS04930	974944..975924	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
EMO93_RS04935	976190..977281	+	1092	WP_000495673.1	hypothetical protein	-
-	977619..977657	+	39	-	-	Antitoxin
EMO93_RS04940	977713..977817	-	105	WP_001802298.1	hypothetical protein	Toxin
EMO93_RS04955	978497..978655	+	159	WP_001792784.1	hypothetical protein	-
EMO93_RS04960	979091..979183	+	93	WP_000220902.1	hypothetical protein	-
EMO93_RS04965	979313..980170	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
EMO93_RS04970	980238..981020	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
EMO93_RS04975	981310..981918	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T117122 WP_001802298.1 NZ_CP035003:c977817-977713 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T117122 NZ_CP035003:c977817-977713 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT117122 NZ_CP035003:977619-977657 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin