Detailed information of TA system TA117103

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3890482..3890740
• Replicon: chromosome
• Accession: NZ_CP034966
• Organism: Escherichia coli strain WCHEC020032

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: C7V17_RS20840
• Protein ID: WP_000809168.1
• Coordinates: 3890588..3890740 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3890482..3890539 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7V17_RS24990	3885536..3886312	+	777	WP_166666977.1	fimbria/pilus outer membrane usher protein	-
C7V17_RS24995	3886487..3886861	+	375	WP_021521651.1	hypothetical protein	-
C7V17_RS20825	3886874..3887832	+	959	Protein_3690	fimbrial family protein	-
C7V17_RS20830	3887871..3888770	-	900	WP_001300855.1	transcriptional activator NhaR	-
C7V17_RS20835	3888836..3890002	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3890482..3890539	-	58	-	-	Antitoxin
C7V17_RS20840	3890588..3890740	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
C7V17_RS20845	3890844..3891974	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
C7V17_RS20850	3892063..3893979	-	1917	WP_000516131.1	molecular chaperone DnaK	-
C7V17_RS20855	3894356..3894760	+	405	WP_000843559.1	DUF2541 family protein	-
C7V17_RS20860	3894786..3895499	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T117103 WP_000809168.1 NZ_CP034966:3890588-3890740 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T117103 NZ_CP034966:3890588-3890740 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT117103 NZ_CP034966:c3890539-3890482 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin