Detailed information of TA system TA117009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 84312..85005
• Replicon: plasmid p.Jk2_1
• Accession: NZ_CP034939
• Organism: Pectobacterium odoriferum strain JK2.1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: EO763_RS23090
• Protein ID: WP_161530540.1
• Coordinates: 84709..85005 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A6P1RVW8
• Locus tag: EO763_RS23085
• Protein ID: WP_039311102.1
• Coordinates: 84312..84707 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EO763_RS23070	80003..80965	-	963	WP_161530537.1	hypothetical protein	-
EO763_RS23075	81692..82588	-	897	WP_161530538.1	DUF4942 domain-containing protein	-
EO763_RS23080	83236..83739	-	504	WP_161530539.1	antirestriction protein ArdA	-
EO763_RS23085	84312..84707	-	396	WP_039311102.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
EO763_RS23090	84709..85005	-	297	WP_161530540.1	type II toxin-antitoxin system MqsR family toxin	Toxin
EO763_RS23095	85010..85237	-	228	WP_161530541.1	hypothetical protein	-
EO763_RS23100	85336..86517	-	1182	WP_161530542.1	hypothetical protein	-
EO763_RS23105	86535..86864	-	330	WP_161530543.1	hypothetical protein	-
EO763_RS23110	87367..87762	+	396	WP_161530544.1	hypothetical protein	-
EO763_RS23115	87809..88183	-	375	WP_161530545.1	hypothetical protein	-
EO763_RS23120	88197..88997	-	801	WP_161530546.1	hypothetical protein	-
EO763_RS23125	89003..89284	-	282	WP_039311124.1	hypothetical protein	-
EO763_RS23130	89294..89479	-	186	WP_161530547.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102326	102326

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10818.61 Da
• Isoelectric Point: 7.3981

>T117009 WP_161530540.1 NZ_CP034939:c85005-84709 [Pectobacterium odoriferum]
MEKQTPHTRLHIVQAMVAAGKVIATKSAVTAAADLGIDREGMHAVIAGLTIKDFYKSMTTYNDHTVWQDVYLPTVDGVKL
YVKVTVIDDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T117009 NZ_CP034939:c85005-84709 [Pectobacterium odoriferum]
ATGGAAAAGCAAACGCCCCATACACGCCTGCATATTGTGCAGGCGATGGTTGCTGCGGGAAAGGTCATCGCAACCAAATC
AGCGGTAACAGCTGCCGCTGATTTGGGGATTGACCGTGAAGGTATGCACGCGGTGATAGCTGGTCTGACAATCAAGGATT
TTTACAAAAGTATGACGACATATAACGATCATACCGTCTGGCAGGATGTGTACCTGCCAACTGTGGACGGGGTGAAGCTG
TATGTTAAAGTTACCGTTATCGATGACGTGTTGATCGTCTCATTTAAGGAGAAATAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14654.78 Da
• Isoelectric Point: 8.1258

>AT117009 WP_039311102.1 NZ_CP034939:c84707-84312 [Pectobacterium odoriferum]
MKCPECGGAELVHDTKDVPYSWRGKKTMLRSVTGLYCPACGEAVLNKEEEAEYRGKMTEFRNSIINDTVEPAYIANIRQR
LSLSQREAGQIFGGGANAFSRYETGKAQPHPSTVKLLKILDLHPDLLKEIR

Nucleotide

• Length: 396 bp

>AT117009 NZ_CP034939:c84707-84312 [Pectobacterium odoriferum]
ATGAAATGTCCTGAGTGTGGCGGTGCCGAACTGGTGCATGACACGAAAGACGTCCCGTATTCGTGGCGGGGTAAAAAAAC
CATGCTGCGCAGCGTGACAGGACTGTATTGCCCTGCATGTGGTGAGGCGGTGCTAAACAAAGAAGAAGAAGCGGAGTATC
GGGGAAAAATGACTGAGTTCAGAAACTCAATTATCAATGACACGGTTGAACCCGCGTACATCGCTAATATTCGGCAACGT
CTGTCATTATCTCAGCGTGAAGCTGGCCAGATTTTTGGCGGCGGTGCGAATGCATTTAGCCGTTATGAAACGGGTAAGGC
ACAACCTCATCCGTCAACGGTGAAATTGTTGAAAATTTTAGATCTCCATCCTGACCTGCTGAAAGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A6P1RVW8