Detailed information of TA system TA117006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 4815120..4816471
• Replicon: chromosome
• Accession: NZ_CP034938
• Organism: Pectobacterium odoriferum strain JK2.1

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: EO763_RS21715
• Protein ID: WP_161530185.1
• Coordinates: 4815431..4816471 (+)
• Length: 347 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A7T5QPJ6
• Locus tag: EO763_RS21710
• Protein ID: WP_039490249.1
• Coordinates: 4815120..4815434 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EO763_RS21685	4810944..4811978	+	1035	WP_010296554.1	putative FMN-dependent luciferase-like monooxygenase	-
EO763_RS21690	4811975..4813108	+	1134	WP_161530184.1	alkylhydroperoxidase domain protein	-
EO763_RS21695	4813165..4813674	-	510	WP_039490245.1	phenolic acid decarboxylase	-
EO763_RS21700	4813777..4814649	+	873	WP_044207317.1	LysR family transcriptional regulator	-
EO763_RS21705	4814809..4815135	+	327	WP_208851970.1	helix-turn-helix domain-containing protein	-
EO763_RS21710	4815120..4815434	+	315	WP_039490249.1	HipA N-terminal domain-containing protein	Antitoxin
EO763_RS21715	4815431..4816471	+	1041	WP_161530185.1	HipA domain-containing protein	Toxin
EO763_RS21720	4816532..4816666	-	135	Protein_4254	LysE family translocator	-
EO763_RS21725	4816865..4817569	+	705	WP_161530186.1	SMI1/KNR4 family protein	-
EO763_RS21730	4817638..4818393	+	756	WP_161530187.1	thiol:disulfide interchange protein DsbG	-
EO763_RS21735	4818428..4819333	-	906	WP_161530188.1	siderophore-interacting protein	-
EO763_RS21740	4819591..4819842	+	252	WP_010281712.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EO763_RS21745	4819839..4820126	+	288	WP_044207310.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (57-307)

Antitoxin

• HipA, N-terminal subdomain 1 (6-98)

Sequences

Toxin

Protein

• Length: 347 a.a.
• Molecular weight: 39583.61 Da
• Isoelectric Point: 6.8641

>T117006 WP_161530185.1 NZ_CP034938:4815431-4816471 [Pectobacterium odoriferum]
MTRCRILLTPLTHEEEMATGYSRKGLKHLTGSMHASPALRFTRQQFMHDLPQAQKGMSISGYQPKIQMVLQDRAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPQHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
AGEKFGKIRTDGRQYVSYERLALFLSKHVNDNVVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSEKLTKKLLADFIKEAECVESTYRDSFMP
AEAIDTTLRCYRHRLNLMSILDAERI

Nucleotide

• Length: 1041 bp

>T117006 NZ_CP034938:4815431-4816471 [Pectobacterium odoriferum]
ATGACAAGATGTCGAATTTTGCTGACACCGCTGACGCATGAAGAAGAGATGGCCACAGGTTATAGCCGTAAAGGGTTGAA
GCATCTGACGGGATCAATGCACGCTTCCCCGGCCTTACGTTTCACCCGACAGCAATTTATGCACGACTTGCCACAAGCAC
AGAAAGGCATGAGCATCTCTGGCTATCAGCCCAAAATTCAGATGGTGTTACAAGATCGGGCATTTACCGTCGTTGATCAT
CAAGGGCTGTACATTCTCAAACCCTCTCCGATTGAATTTCCCCATTTGGCAGAAAACGAACACGCCACGATGACGCTAAT
GGCACGCCTGGGGTTTGCCGTTCCACAACACGGGTTACTCCGTTTTAAACCGGAGCAGGCTGATGACGAACCTGAGTTTG
CTTTCGTTATTAAGCGCTTCGACCGCGACGAAAAAACGGGTCACCCTATCCATCAGGAACAGTTAGACGGTGCGATGGGG
GCCGGTGAAAAATTCGGTAAAATACGAACAGATGGCAGGCAATACGTCAGTTATGAGCGGTTGGCTTTATTCCTTAGCAA
ACACGTTAATGACAATGTCGTCTTCAAAATAGATCTGTTTCGCCGCATCGCTTACGCCTACATGCTGGGTAACAACGATA
TGCACCTGCGTAATTTTGGGCTGATACATTCGCGCTCAGGCCAATTAATGCTGGCCCCTATTTATGACTTTGTTTCCGTC
GCCCCCTATCCCACCTATTTTTCTTCCTGCTTCATGGCACTACCGCTGCTGATTCAAGAAGAGGGGGATGAAGCGCTCGC
ACCCGGCTTTGAAACCGCGTACGGAGAGTATCTGGGTATGGATTTCATTCTGTTCGGACAGCGTATCGGGCTGAGTGAAA
AGCTTACCAAAAAGCTACTGGCAGACTTCATCAAAGAAGCTGAATGCGTTGAATCAACCTATCGGGATTCCTTTATGCCT
GCGGAGGCGATTGATACGACGCTGCGGTGCTATCGACACCGCCTGAATCTTATGAGCATTCTCGATGCAGAACGGATTTA
G

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11850.72 Da
• Isoelectric Point: 9.7865

>AT117006 WP_039490249.1 NZ_CP034938:4815120-4815434 [Pectobacterium odoriferum]
VRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGIFRSKTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKA

Nucleotide

• Length: 315 bp

>AT117006 NZ_CP034938:4815120-4815434 [Pectobacterium odoriferum]
GTGCGCCGTCAAGTAAAAGTCTACCTTTACGGTGTCCACATCGGCCAGTTAAGTCAGGACGATAAAGGCTATTTGTTTGA
ATATAAAAAGTCCTACATCGGCCCGCCATTATCCTTGAGCCTACCGATACAGACCGGAATATTTCGCAGCAAAACATTGC
CGCCCTATTTCGCCTCGTTAGCCCCCGAAGGCTGGCTCCGGCGCCAGTACAGCCAGCTACAACATCTGGATGAGAAAGAC
CTATTTGGTATCCTCATTCAAAACGGTAAGAATCTGATCGGCGCCGTACAACTGATTGCAGAGGATAAAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7T5QPJ6