Detailed information of TA system TA116990

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4565508..4565733
• Replicon: chromosome
• Accession: NZ_CP034935
• Organism: Shigella dysenteriae strain 79-8006

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: EPD85_RS24075
• Protein ID: WP_000813254.1
• Coordinates: 4565578..4565733 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4565508..4565566 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPD85_RS24035	4560871..4561293	+	423	WP_001151146.1	DUF977 family protein	-
EPD85_RS24040	4561290..4561595	+	306	WP_001266147.1	DUF4406 domain-containing protein	-
EPD85_RS24045	4561582..4562037	+	456	WP_000335375.1	ead/Ea22-like family protein	-
EPD85_RS24050	4562087..4563625	-	1539	WP_000099181.1	IS66-like element ISEc22 family transposase	-
EPD85_RS24055	4563674..4564021	-	348	WP_000612610.1	IS66 family insertion sequence element accessory protein TnpB	-
EPD85_RS24060	4564018..4564398	-	381	WP_001333468.1	transposase	-
EPD85_RS24065	4564510..4564926	+	417	WP_005069274.1	hypothetical protein	-
-	4565508..4565566	-	59	-	-	Antitoxin
EPD85_RS24075	4565578..4565733	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
EPD85_RS24080	4565901..4566179	+	279	WP_000929754.1	hypothetical protein	-
EPD85_RS24085	4566181..4566930	+	750	Protein_4582	hypothetical protein	-
EPD85_RS24090	4566980..4567908	-	929	Protein_4583	IS3-like element IS600 family transposase	-
EPD85_RS25450	4568677..4568745	+	69	Protein_4585	phage tail protein	-
EPD85_RS24100	4568748..4569293	+	546	WP_000902849.1	tail fiber assembly protein	-
EPD85_RS24105	4569317..4570585	+	1269	Protein_4587	prophage tail fiber N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	4554958..4595447	40489
	-	inside	IScluster/Tn	-	-	4557048..4568301	11253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T116990 WP_000813254.1 NZ_CP034935:4565578-4565733 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T116990 NZ_CP034935:4565578-4565733 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT116990 NZ_CP034935:c4565566-4565508 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin