116987

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3773230..3773957 Replicon chromosome
Accession NZ_CP034935
Organism Shigella dysenteriae strain 79-8006

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag EPD85_RS20060 Protein ID WP_000550189.1
Coordinates 3773230..3773544 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EPD85_RS20065 Protein ID WP_000560263.1
Coordinates 3773541..3773957 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPD85_RS20040 (3769396) 3769396..3770382 - 987 WP_004986115.1 Gfo/Idh/MocA family oxidoreductase -
EPD85_RS20045 (3770461) 3770461..3771144 - 684 WP_001183035.1 vancomycin high temperature exclusion protein -
EPD85_RS20050 (3771221) 3771221..3771724 - 504 WP_001295542.1 M48 family metallopeptidase -
EPD85_RS20055 (3771809) 3771809..3772945 + 1137 WP_000018665.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
EPD85_RS20060 (3773230) 3773230..3773544 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
EPD85_RS20065 (3773541) 3773541..3773957 + 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
EPD85_RS20070 (3774002) 3774002..3776020 - 2019 WP_000121440.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
EPD85_RS20075 (3776246) 3776246..3778597 - 2352 Protein_3807 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T116987 WP_000550189.1 NZ_CP034935:3773230-3773544 [Shigella dysenteriae]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T116987 NZ_CP034935:3773230-3773544 [Shigella dysenteriae]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT116987 WP_000560263.1 NZ_CP034935:3773541-3773957 [Shigella dysenteriae]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT116987 NZ_CP034935:3773541-3773957 [Shigella dysenteriae]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTGCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References