Detailed information of TA system TA116983

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2955717..2955974
• Replicon: chromosome
• Accession: NZ_CP034935
• Organism: Shigella dysenteriae strain 79-8006

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: Q31V67
• Locus tag: EPD85_RS15895
• Protein ID: WP_001135724.1
• Coordinates: 2955717..2955869 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2955920..2955974 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPD85_RS15865	2951121..2951708	+	588	WP_000747616.1	OmpA family lipoprotein	-
EPD85_RS15870	2951812..2952786	+	975	WP_000805034.1	glyoxylate/hydroxypyruvate reductase GhrB	-
EPD85_RS15875	2952836..2953546	-	711	WP_004987320.1	DUF3053 domain-containing protein	-
EPD85_RS15880	2953803..2954500	+	698	WP_134795416.1	IS1-like element IS1SD family transposase	-
EPD85_RS15885	2954755..2955045	+	291	WP_005045913.1	HTH-type transcriptional regulator	-
EPD85_RS15890	2955326..2955538	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
EPD85_RS25285	2955669..2955728	+	60	WP_212732943.1	hypothetical protein	-
EPD85_RS15895	2955717..2955869	-	153	WP_001135724.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2955920..2955974	+	55	-	-	Antitoxin
EPD85_RS15900	2956133..2956830	+	698	WP_094106546.1	IS1 family transposase	-
EPD85_RS15905	2957134..2958362	+	1229	WP_088895425.1	IS3-like element IS2 family transposase	-
EPD85_RS15910	2958376..2959518	-	1143	Protein_2977	IS4-like element IS4 family transposase	-
EPD85_RS15915	2959669..2960025	+	357	WP_000239757.1	transposase	-
EPD85_RS15920	2960022..2960231	+	210	Protein_2979	IS66 family insertion sequence element accessory protein TnpB	-
EPD85_RS15925	2960235..2960465	+	231	Protein_2980	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2954123..2960025	5902

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5868.09 Da
• Isoelectric Point: 7.7173

>T116983 WP_001135724.1 NZ_CP034935:c2955869-2955717 [Shigella dysenteriae]
MPQKYGLLSLIVICFTLLFFTWMVRDSLCELHIKQGRYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T116983 NZ_CP034935:c2955869-2955717 [Shigella dysenteriae]
ATGCCGCAAAAATACGGATTACTTTCATTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGGTAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGCGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT116983 NZ_CP034935:2955920-2955974 [Shigella dysenteriae]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: Q31V67

Antitoxin