Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1971923..1972181 Replicon chromosome
Accession NZ_CP034935
Organism Shigella dysenteriae strain 79-8006

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag EPD85_RS11040 Protein ID WP_000809168.1
Coordinates 1972029..1972181 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 1971923..1971980 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPD85_RS11025 1968840..1969274 + 435 Protein_2038 fimbrial family protein -
EPD85_RS11030 1969312..1970211 - 900 WP_001300855.1 transcriptional activator NhaR -
EPD85_RS11035 1970277..1971443 - 1167 WP_000681373.1 Na+/H+ antiporter NhaA -
- 1971923..1971980 - 58 - - Antitoxin
EPD85_RS11040 1972029..1972181 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
EPD85_RS11045 1972285..1973400 - 1116 WP_001118451.1 molecular chaperone DnaJ -
EPD85_RS11050 1973489..1975405 - 1917 WP_000516135.1 molecular chaperone DnaK -
EPD85_RS11055 1975782..1976012 + 231 Protein_2044 DUF2541 family protein -
EPD85_RS11060 1976067..1976764 + 698 WP_094106546.1 IS1 family transposase -
EPD85_RS11065 1976787..1976963 + 177 Protein_2046 DUF2541 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1976261..1976764 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T116981 WP_000809168.1 NZ_CP034935:1972029-1972181 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T116981 NZ_CP034935:1972029-1972181 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT116981 NZ_CP034935:c1971980-1971923 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References