Detailed information of TA system TA116981

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1971923..1972181
• Replicon: chromosome
• Accession: NZ_CP034935
• Organism: Shigella dysenteriae strain 79-8006

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: EPD85_RS11040
• Protein ID: WP_000809168.1
• Coordinates: 1972029..1972181 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1971923..1971980 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPD85_RS11025	1968840..1969274	+	435	Protein_2038	fimbrial family protein	-
EPD85_RS11030	1969312..1970211	-	900	WP_001300855.1	transcriptional activator NhaR	-
EPD85_RS11035	1970277..1971443	-	1167	WP_000681373.1	Na+/H+ antiporter NhaA	-
-	1971923..1971980	-	58	-	-	Antitoxin
EPD85_RS11040	1972029..1972181	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
EPD85_RS11045	1972285..1973400	-	1116	WP_001118451.1	molecular chaperone DnaJ	-
EPD85_RS11050	1973489..1975405	-	1917	WP_000516135.1	molecular chaperone DnaK	-
EPD85_RS11055	1975782..1976012	+	231	Protein_2044	DUF2541 family protein	-
EPD85_RS11060	1976067..1976764	+	698	WP_094106546.1	IS1 family transposase	-
EPD85_RS11065	1976787..1976963	+	177	Protein_2046	DUF2541 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1976261..1976764	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T116981 WP_000809168.1 NZ_CP034935:1972029-1972181 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T116981 NZ_CP034935:1972029-1972181 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT116981 NZ_CP034935:c1971980-1971923 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin