Detailed information of TA system TA116978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 712500..712725
• Replicon: chromosome
• Accession: NZ_CP034935
• Organism: Shigella dysenteriae strain 79-8006

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: EPD85_RS04555
• Protein ID: WP_000813254.1
• Coordinates: 712500..712655 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	712667..712725 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPD85_RS04520	707802..708860	-	1059	WP_000935541.1	site-specific DNA-methyltransferase	-
EPD85_RS04525	708968..709208	-	241	Protein_771	hypothetical protein	-
EPD85_RS04530	709434..710255	-	822	WP_000762933.1	antitermination protein	-
EPD85_RS04535	710252..710626	-	375	WP_073817556.1	RusA family crossover junction endodeoxyribonuclease	-
EPD85_RS04540	710639..711685	-	1047	WP_001265091.1	DUF968 domain-containing protein	-
EPD85_RS04545	711687..711965	-	279	WP_032335658.1	hypothetical protein	-
EPD85_RS04550	712032..712283	-	252	WP_000980988.1	protein Rem	-
EPD85_RS04555	712500..712655	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	712667..712725	+	59	-	-	Antitoxin
EPD85_RS04560	712947..713180	-	234	WP_000350274.1	hypothetical protein	-
EPD85_RS24705	714623..714790	-	168	WP_000207997.1	hypothetical protein	-
EPD85_RS04570	714801..715064	-	264	WP_000224216.1	hypothetical protein	-
EPD85_RS04575	715066..715284	-	219	WP_001142588.1	DUF4014 family protein	-
EPD85_RS04580	715286..715501	-	216	WP_000510387.1	hypothetical protein	-
EPD85_RS04585	715502..715861	-	360	WP_001289986.1	hypothetical protein	-
EPD85_RS24710	715858..716034	-	177	WP_000753053.1	hypothetical protein	-
EPD85_RS04590	716027..716209	-	183	WP_001224665.1	hypothetical protein	-
EPD85_RS04595	716305..716661	-	357	WP_000403782.1	hypothetical protein	-
EPD85_RS04600	716639..717100	-	462	WP_001209470.1	sigma-E factor regulatory protein RseB domain-containing protein	-
EPD85_RS04605	717097..717393	-	297	WP_001266130.1	DUF4406 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	673971..750164	76193

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T116978 WP_000813254.1 NZ_CP034935:c712655-712500 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T116978 NZ_CP034935:c712655-712500 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT116978 NZ_CP034935:712667-712725 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin