Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1373528..1373753 Replicon chromosome
Accession NZ_CP034931
Organism Shigella flexneri strain 2013C-3749

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag EPD86_RS06860 Protein ID WP_000813254.1
Coordinates 1373598..1373753 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1373528..1373586 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPD86_RS06820 1368705..1369967 - 1263 Protein_1322 tyrosine-type recombinase/integrase -
EPD86_RS06830 1370305..1371102 - 798 WP_001325918.1 DgsA anti-repressor MtfA -
EPD86_RS06840 1371313..1372363 - 1051 Protein_1324 tyrosine-type recombinase/integrase -
EPD86_RS06845 1372363..1372503 - 141 Protein_1325 DUF4224 domain-containing protein -
EPD86_RS06850 1372530..1372946 + 417 WP_005069274.1 hypothetical protein -
- 1373528..1373586 - 59 - - Antitoxin
EPD86_RS06860 1373598..1373753 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
EPD86_RS06865 1373921..1374199 + 279 WP_011069426.1 hypothetical protein -
EPD86_RS06870 1374201..1375259 + 1059 WP_001265248.1 DUF968 domain-containing protein -
EPD86_RS06875 1375260..1375625 + 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
EPD86_RS06880 1375622..1376310 + 689 Protein_1331 bacteriophage antitermination protein Q -
EPD86_RS06905 1377106..1377321 + 216 WP_000839572.1 class II holin family protein -
EPD86_RS06910 1377420..1378094 + 675 WP_004967157.1 IS66-like element accessory protein TnpA -
EPD86_RS06915 1378091..1378441 + 351 WP_005049241.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 1364144..1406380 42236


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T116940 WP_000813254.1 NZ_CP034931:1373598-1373753 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T116940 NZ_CP034931:1373598-1373753 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT116940 NZ_CP034931:c1373586-1373528 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References