Detailed information of TA system TA116912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 6169185..6169872
• Replicon: chromosome
• Accession: NZ_CP034836
• Organism: Hahella sp. KA22

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ENC22_RS27370
• Protein ID: WP_127973746.1
• Coordinates: 6169185..6169544 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ENC22_RS27375
• Protein ID: WP_127973747.1
• Coordinates: 6169561..6169872 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENC22_RS27355	6167272..6167592	+	321	WP_127973744.1	XRE family transcriptional regulator	-
ENC22_RS27360	6167632..6168684	+	1053	WP_127973745.1	tyrosine-type recombinase/integrase	-
ENC22_RS27370	6169185..6169544	+	360	WP_127973746.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ENC22_RS27375	6169561..6169872	+	312	WP_127973747.1	XRE family transcriptional regulator	Antitoxin
ENC22_RS27380	6169898..6171685	+	1788	WP_164887395.1	DEAD/DEAH box helicase family protein	-
ENC22_RS27385	6172130..6172375	-	246	WP_127973749.1	hypothetical protein	-
ENC22_RS27390	6172365..6172844	-	480	WP_127973750.1	hypothetical protein	-
ENC22_RS27395	6172864..6174348	-	1485	WP_127974618.1	MobA/MobL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	6128407..6190866	62459

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-84)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13568.68 Da
• Isoelectric Point: 8.0084

>T116912 WP_127973746.1 NZ_CP034836:6169185-6169544 [Hahella sp. KA22]
MTWEILVTDEYEGWFLNLTDAEQIDVQAMVDVLEIKGPNLGRPQADTIKGTKKVKNLKELVIQHAGKPYRVFYAFDPKRR
AVLLCGGRKDGSKDKQFYKQMVPLAEAEFADHLKSEGLK

Nucleotide

• Length: 360 bp

>T116912 NZ_CP034836:6169185-6169544 [Hahella sp. KA22]
ATGACGTGGGAAATATTAGTCACAGATGAATATGAGGGCTGGTTTCTAAATCTAACTGACGCTGAACAAATTGACGTTCA
AGCAATGGTTGACGTTCTGGAAATCAAAGGCCCTAACCTTGGCCGCCCTCAGGCAGATACGATAAAAGGCACAAAGAAGG
TTAAAAACCTTAAGGAGCTGGTCATTCAGCACGCAGGAAAACCATATAGAGTTTTCTATGCCTTTGACCCCAAACGACGC
GCTGTTCTTCTATGCGGTGGTCGAAAAGATGGATCGAAAGATAAACAGTTTTACAAACAGATGGTTCCGCTAGCTGAAGC
AGAGTTTGCGGATCACTTAAAAAGCGAAGGCCTCAAGTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11129.92 Da
• Isoelectric Point: 10.4004

>AT116912 WP_127973747.1 NZ_CP034836:6169561-6169872 [Hahella sp. KA22]
MAKPLSELRKQMSPEVQAAARAKAVGIVAEMSLAETRKLRGRSQAVVARALGIAQPNVSQIEKRPDTMISTLASYVEALG
GKLEIHAKFPDGQDVEITQFKQA

Nucleotide

• Length: 312 bp

>AT116912 NZ_CP034836:6169561-6169872 [Hahella sp. KA22]
ATGGCAAAGCCTTTAAGCGAACTGCGCAAGCAAATGAGCCCTGAAGTACAAGCAGCCGCACGAGCAAAAGCAGTTGGCAT
AGTTGCAGAAATGTCACTGGCAGAAACTCGTAAGCTGCGTGGTCGCAGTCAAGCAGTGGTGGCTCGCGCCTTGGGTATAG
CCCAACCTAATGTTTCTCAAATTGAAAAACGCCCTGACACAATGATCAGCACACTGGCGTCTTATGTTGAAGCCTTAGGT
GGAAAACTCGAAATCCATGCAAAATTTCCAGATGGGCAAGACGTGGAGATCACACAATTCAAACAAGCTTGA