Detailed information of TA system TA116907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4484284..4485038
• Replicon: chromosome
• Accession: NZ_CP034831
• Organism: Salmonella sp. SSDFZ69

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3Z1E8E0
• Locus tag: EOS98_RS22170
• Protein ID: WP_000558163.1
• Coordinates: 4484284..4484595 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EOS98_RS22175
• Protein ID: WP_001259009.1
• Coordinates: 4484592..4485038 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOS98_RS22140	4479942..4480844	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
EOS98_RS22145	4480841..4481476	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
EOS98_RS22150	4481473..4482402	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
EOS98_RS22155	4482449..4482739	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
EOS98_RS22160	4482740..4483051	-	312	WP_023138876.1	hypothetical protein	-
EOS98_RS22165	4483269..4484198	+	930	WP_126524392.1	alpha/beta hydrolase	-
EOS98_RS22170	4484284..4484595	+	312	WP_000558163.1	type II toxin-antitoxin system HigB family toxin	Toxin
EOS98_RS22175	4484592..4485038	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
EOS98_RS22180	4485053..4485994	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
EOS98_RS22185	4486039..4486476	-	438	WP_000560969.1	D-tyrosyl-tRNA(Tyr) deacylase	-
EOS98_RS22190	4486473..4487345	-	873	WP_000921423.1	virulence factor BrkB family protein	-
EOS98_RS22195	4487339..4487938	-	600	WP_000965695.1	glucose-1-phosphatase	-
EOS98_RS22200	4488129..4488932	-	804	WP_021000967.1	DeoR/GlpR family DNA-binding transcription regulator	-
EOS98_RS22205	4488966..4489862	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12406.36 Da
• Isoelectric Point: 9.5921

>T116907 WP_000558163.1 NZ_CP034831:4484284-4484595 [Salmonella sp. SSDFZ69]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T116907 NZ_CP034831:4484284-4484595 [Salmonella sp. SSDFZ69]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT116907 WP_001259009.1 NZ_CP034831:4484592-4485038 [Salmonella sp. SSDFZ69]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT116907 NZ_CP034831:4484592-4485038 [Salmonella sp. SSDFZ69]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A3Z1E8E0