Detailed information of TA system TA116884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4008412..4009139
• Replicon: chromosome
• Accession: NZ_CP034819
• Organism: Salmonella sp. SSDFZ54

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8E5IJ81
• Locus tag: EOS97_RS19855
• Protein ID: WP_000558157.1
• Coordinates: 4008828..4009139 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EOS97_RS19850
• Protein ID: WP_000561389.1
• Coordinates: 4008412..4008831 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOS97_RS19820	4005219..4005760	+	542	Protein_3730	transposase	-
EOS97_RS19825	4005906..4006046	-	141	WP_001640444.1	hypothetical protein	-
EOS97_RS19830	4006215..4006481	-	267	WP_077906534.1	hypothetical protein	-
EOS97_RS19840	4006851..4007270	+	420	WP_000354401.1	GNAT family N-acetyltransferase	-
EOS97_RS19845	4007506..4008159	-	654	Protein_3734	glycosyltransferase	-
EOS97_RS19850	4008412..4008831	-	420	WP_000561389.1	helix-turn-helix domain-containing protein	Antitoxin
EOS97_RS19855	4008828..4009139	-	312	WP_000558157.1	type II toxin-antitoxin system HigB family toxin	Toxin
EOS97_RS19860	4009318..4009617	+	300	WP_000775226.1	hypothetical protein	-
EOS97_RS19865	4009647..4009856	+	210	WP_000754426.1	hypothetical protein	-
EOS97_RS19870	4009960..4010517	+	558	WP_000179886.1	hypothetical protein	-
EOS97_RS19875	4010788..4011246	+	459	WP_001195655.1	hypothetical protein	-
EOS97_RS19880	4011358..4011552	-	195	WP_001805175.1	hypothetical protein	-
EOS97_RS19885	4011662..4012138	-	477	WP_000030951.1	hypothetical protein	-
EOS97_RS19890	4012467..4012862	-	396	WP_000422887.1	DUF1398 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	sopE2	4005147..4014717	9570
	-	flank	IS/Tn	-	-	4005422..4005760	338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (85-138)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12425.26 Da
• Isoelectric Point: 10.1376

>T116884 WP_000558157.1 NZ_CP034819:c4009139-4008828 [Salmonella sp. SSDFZ54]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE

Nucleotide

• Length: 312 bp

>T116884 NZ_CP034819:c4009139-4008828 [Salmonella sp. SSDFZ54]
ATGCATGTCATATCAAAAGAGCCTTTTGATGAAGCGGCAAGACGATATCCCAATGACTCGTTAGCCATAAAAGCCCTGTA
TCGCTTAGTCCGCGAAAAAGATTTCTCTTCTCCGGCAGAGCTACGAAAGGTCATACCGAGTCTCGATAACTTTAAGTACC
GTAACAAGTGGTGGGTACTGGATGTCGGAGGCAACAACCTGAGGGTGATCGCTTACATCAACTTTATAAACAAACGCTTT
TATGTGAAACACATCGCCACTCACGCTGAATATGACAAGCTGACCCGCTACTACAGGGAGAATAAAGAATGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15301.49 Da
• Isoelectric Point: 4.6286

>AT116884 WP_000561389.1 NZ_CP034819:c4008831-4008412 [Salmonella sp. SSDFZ54]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Nucleotide

• Length: 420 bp

>AT116884 NZ_CP034819:c4008831-4008412 [Salmonella sp. SSDFZ54]
ATGATTGCCAACACCGCAAAAGCTATCGAAGCCACAAAGGCGCTGGTCGCCGCCGTTCCTTTCCTGGGTGGCAGCGCGTC
AGAGAAAGATTATCGTGATGCGCTGGCGCTGGTTGATTATCTTATCGAAAATGACGATGAAAACCCGCTGATTGACTTCC
TGGCAAGCAAAATTGCCGAGTACGAAGATAACAGCAAGCAGTTCGCCGAGTTCAACAAATCTGTTGCTGAAATGCCGGTT
GGCGTTGCCCTGCTGCGCACGCTAATTGACCAGTACAAACTCTCATACTCAGATCTTAAAGAAGAGATCGGTTCCAAATC
ACTGGTAAGTCAGATCCTGTCCGGACAGCGCTCGTTAACGATTACGCACATCAAAGCGCTTTCAGCACGATTTGGCGTGA
AACCTGAGTGGTTCTTATAA