Detailed information of TA system TA116870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 2138533..2139135
• Replicon: chromosome
• Accession: NZ_CP034819
• Organism: Salmonella sp. SSDFZ54

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V4SQH3
• Locus tag: EOS97_RS10695
• Protein ID: WP_001159628.1
• Coordinates: 2138533..2138844 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EOS97_RS10700
• Protein ID: WP_000362050.1
• Coordinates: 2138845..2139135 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOS97_RS10660	2133646..2134245	+	600	WP_000965695.1	glucose-1-phosphatase	-
EOS97_RS10665	2134239..2135111	+	873	WP_000921423.1	virulence factor BrkB family protein	-
EOS97_RS10670	2135108..2135545	+	438	WP_000560969.1	D-tyrosyl-tRNA(Tyr) deacylase	-
EOS97_RS10675	2135590..2136531	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
EOS97_RS10680	2136546..2136992	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
EOS97_RS10685	2136989..2137300	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
EOS97_RS10690	2137386..2138315	-	930	WP_001127701.1	alpha/beta hydrolase	-
EOS97_RS10695	2138533..2138844	+	312	WP_001159628.1	hypothetical protein	Toxin
EOS97_RS10700	2138845..2139135	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
EOS97_RS10705	2139182..2140111	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
EOS97_RS10710	2140108..2140743	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
EOS97_RS10715	2140740..2141642	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12376.29 Da
• Isoelectric Point: 9.4460

>T116870 WP_001159628.1 NZ_CP034819:2138533-2138844 [Salmonella sp. SSDFZ54]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T116870 NZ_CP034819:2138533-2138844 [Salmonella sp. SSDFZ54]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGTTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT116870 WP_000362050.1 NZ_CP034819:2138845-2139135 [Salmonella sp. SSDFZ54]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT116870 NZ_CP034819:2138845-2139135 [Salmonella sp. SSDFZ54]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACTCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A3V4SQH3