Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5465331..5466126 Replicon chromosome
Accession NZ_CP034808
Organism Escherichia coli strain 08-3914

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag AYP36_RS27845 Protein ID WP_000854914.1
Coordinates 5465331..5465705 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag AYP36_RS27850 Protein ID WP_001280954.1
Coordinates 5465752..5466126 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYP36_RS27805 5460335..5460826 - 492 WP_001301587.1 DUF1097 domain-containing protein -
AYP36_RS27810 5460928..5461482 - 555 WP_001001917.1 molecular chaperone YcdY -
AYP36_RS27815 5461506..5462243 - 738 WP_000283664.1 zinc-binding phosphatase -
AYP36_RS27820 5462298..5463236 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
AYP36_RS27830 5463707..5464549 - 843 WP_001280481.1 DUF4942 domain-containing protein -
AYP36_RS27835 5464634..5464831 - 198 WP_000839282.1 DUF957 domain-containing protein -
AYP36_RS27840 5464843..5465334 - 492 WP_000976853.1 hypothetical protein -
AYP36_RS27845 5465331..5465705 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
AYP36_RS27850 5465752..5466126 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AYP36_RS27855 5466289..5466510 - 222 WP_001220314.1 DUF987 domain-containing protein -
AYP36_RS27860 5466573..5467049 - 477 WP_001186738.1 RadC family protein -
AYP36_RS27865 5467065..5467550 - 486 WP_000214398.1 antirestriction protein -
AYP36_RS27870 5467641..5468459 - 819 WP_001234682.1 DUF945 domain-containing protein -
AYP36_RS27880 5468799..5469869 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
AYP36_RS27885 5469866..5470771 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgA / csgB / csgD / csgE / csgF / csgG 5456218..5467550 11332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T116861 WP_000854914.1 NZ_CP034808:c5465705-5465331 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T116861 NZ_CP034808:c5465705-5465331 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT116861 WP_001280954.1 NZ_CP034808:c5466126-5465752 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT116861 NZ_CP034808:c5466126-5465752 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References