Detailed information of TA system TA116858

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4776843..4777068
• Replicon: chromosome
• Accession: NZ_CP034808
• Organism: Escherichia coli strain 08-3914

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: AYP36_RS24075
• Protein ID: WP_000813258.1
• Coordinates: 4776913..4777068 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4776843..4776901 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYP36_RS24025	4771908..4772150	+	243	WP_000747948.1	hypothetical protein	-
AYP36_RS24030	4772134..4772559	+	426	WP_000693878.1	Rha family transcriptional regulator	-
AYP36_RS24035	4772628..4773671	+	1044	WP_001262402.1	hypothetical protein	-
AYP36_RS24040	4773664..4774125	+	462	WP_000139447.1	replication protein	-
AYP36_RS24045	4774159..4774875	+	717	WP_000450627.1	DUF1627 domain-containing protein	-
AYP36_RS24050	4774908..4775189	+	282	WP_000603384.1	DNA-binding protein	-
AYP36_RS24055	4775186..4775413	+	228	WP_000699809.1	hypothetical protein	-
AYP36_RS24060	4775406..4775717	+	312	WP_001289673.1	hypothetical protein	-
AYP36_RS24065	4775845..4776063	+	219	WP_000683609.1	DUF4014 family protein	-
AYP36_RS24070	4776065..4776622	+	558	WP_000104474.1	DUF551 domain-containing protein	-
-	4776843..4776901	-	59	-	-	Antitoxin
AYP36_RS24075	4776913..4777068	+	156	WP_000813258.1	type I toxin-antitoxin system Hok family toxin	Toxin
AYP36_RS24080	4777188..4777532	+	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
AYP36_RS24085	4777654..4777926	+	273	WP_000191870.1	hypothetical protein	-
AYP36_RS24090	4777928..4778977	+	1050	WP_001265229.1	DUF968 domain-containing protein	-
AYP36_RS24095	4778990..4779295	+	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
AYP36_RS24100	4779358..4779912	+	555	WP_000640035.1	DUF1133 family protein	-
AYP36_RS24105	4780137..4780334	+	198	WP_000917763.1	hypothetical protein	-
AYP36_RS24110	4780470..4781183	+	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
AYP36_RS24125	4781638..4782066	+	429	WP_001303509.1	tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	4702017..4832200	130183

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T116858 WP_000813258.1 NZ_CP034808:4776913-4777068 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T116858 NZ_CP034808:4776913-4777068 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT116858 NZ_CP034808:c4776901-4776843 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin