Detailed information of TA system TA116824

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 4914406..4914627
• Replicon: chromosome
• Accession: NZ_CP034806
• Organism: Escherichia coli strain 2010C-3347

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: A1D75_RS25475
• Protein ID: WP_001295224.1
• Coordinates: 4914406..4914513 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4914562..4914627 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1D75_RS25450	4909659..4910411	-	753	Protein_4837	cellulose biosynthesis protein BcsQ	-
A1D75_RS25455	4910423..4910611	-	189	WP_001063316.1	YhjR family protein	-
A1D75_RS25460	4910884..4912455	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
A1D75_RS25465	4912452..4912643	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
A1D75_RS25470	4912640..4914319	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
A1D75_RS25475	4914406..4914513	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4914562..4914627	+	66	NuclAT_17	-	Antitoxin
-	4914562..4914627	+	66	NuclAT_17	-	Antitoxin
-	4914562..4914627	+	66	NuclAT_17	-	Antitoxin
-	4914562..4914627	+	66	NuclAT_17	-	Antitoxin
-	4914562..4914627	+	66	NuclAT_22	-	Antitoxin
-	4914562..4914627	+	66	NuclAT_22	-	Antitoxin
-	4914562..4914627	+	66	NuclAT_22	-	Antitoxin
-	4914562..4914627	+	66	NuclAT_22	-	Antitoxin
A1D75_RS25480	4914989..4916254	+	1266	WP_001481782.1	amino acid permease	-
A1D75_RS25485	4916284..4917288	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
A1D75_RS25490	4917285..4918268	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
A1D75_RS25495	4918279..4919181	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T116824 WP_001295224.1 NZ_CP034806:c4914513-4914406 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T116824 NZ_CP034806:c4914513-4914406 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT116824 NZ_CP034806:4914562-4914627 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin