Detailed information of TA system TA116808

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1820538..1820909
• Replicon: chromosome
• Accession: NZ_CP034806
• Organism: Escherichia coli strain 2010C-3347

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: A1D75_RS09070
• Protein ID: WP_001443846.1
• Coordinates: 1820760..1820909 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1820538..1820716 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1D75_RS29085	1816290..1816460	+	171	WP_001625136.1	hypothetical protein	-
A1D75_RS09045	1816493..1817866	+	1374	WP_000123746.1	ATP-dependent RNA helicase DbpA	-
A1D75_RS09050	1817995..1818930	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A1D75_RS09055	1818982..1820217	-	1236	WP_000040839.1	site-specific integrase	-
A1D75_RS09060	1820219..1820434	-	216	WP_000079604.1	excisionase XisR	-
A1D75_RS09065	1820534..1820722	-	189	WP_001302840.1	DUF1187 family protein	-
-	1820538..1820716	+	179	NuclAT_0	-	Antitoxin
-	1820538..1820716	+	179	NuclAT_0	-	Antitoxin
-	1820538..1820716	+	179	NuclAT_0	-	Antitoxin
-	1820538..1820716	+	179	NuclAT_0	-	Antitoxin
A1D75_RS09070	1820760..1820909	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A1D75_RS09075	1820965..1821774	-	810	WP_000166313.1	recombination protein RecT	-
A1D75_RS09080	1821767..1824367	-	2601	WP_000105140.1	exodeoxyribonuclease VIII	-
A1D75_RS09085	1824469..1824744	-	276	WP_001344816.1	hypothetical protein	-
A1D75_RS09090	1824819..1824989	-	171	WP_001352098.1	conserved protein, Rac prophage	-
A1D75_RS09095	1824989..1825210	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1805916..1868134	62218

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T116808 WP_001443846.1 NZ_CP034806:c1820909-1820760 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T116808 NZ_CP034806:c1820909-1820760 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT116808 NZ_CP034806:1820538-1820716 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin