Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2000236..2000775 Replicon chromosome
Accession NZ_CP034803
Organism Escherichia coli strain 2009C-3554

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag A0I22_RS10785 Protein ID WP_001303998.1
Coordinates 2000515..2000775 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag A0I22_RS10780 Protein ID WP_000729705.1
Coordinates 2000236..2000496 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0I22_RS10760 1995990..1996775 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
A0I22_RS10765 1996747..1998459 + 1713 Protein_2023 flagellar biosynthesis protein FlhA -
A0I22_RS10770 1998604..1999101 - 498 Protein_2024 REP-associated tyrosine transposase RayT -
A0I22_RS10775 1999277..2000050 - 774 WP_000543891.1 C40 family peptidase -
A0I22_RS10780 2000236..2000496 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
A0I22_RS10785 2000515..2000775 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
A0I22_RS10790 2000931..2001671 + 741 WP_001225679.1 murein L,D-transpeptidase -
A0I22_RS10795 2001642..2002409 - 768 WP_001301698.1 class II glutamine amidotransferase -
A0I22_RS10800 2002514..2003092 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T116764 WP_001303998.1 NZ_CP034803:2000515-2000775 [Escherichia coli]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T116764 NZ_CP034803:2000515-2000775 [Escherichia coli]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT116764 WP_000729705.1 NZ_CP034803:2000236-2000496 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT116764 NZ_CP034803:2000236-2000496 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References