Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5419921..5420716 Replicon chromosome
Accession NZ_CP034801
Organism Escherichia coli strain 2010C-3142

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag AYR10_RS27590 Protein ID WP_000854914.1
Coordinates 5419921..5420295 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag AYR10_RS27595 Protein ID WP_001280954.1
Coordinates 5420342..5420716 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR10_RS27550 5414925..5415416 - 492 WP_001301587.1 DUF1097 domain-containing protein -
AYR10_RS27555 5415518..5416072 - 555 WP_001001917.1 molecular chaperone YcdY -
AYR10_RS27560 5416096..5416833 - 738 WP_000283664.1 zinc-binding phosphatase -
AYR10_RS27565 5416888..5417826 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
AYR10_RS27575 5418297..5419139 - 843 WP_001280481.1 DUF4942 domain-containing protein -
AYR10_RS27580 5419224..5419421 - 198 WP_000839282.1 DUF957 domain-containing protein -
AYR10_RS27585 5419433..5419924 - 492 WP_000976853.1 hypothetical protein -
AYR10_RS27590 5419921..5420295 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
AYR10_RS27595 5420342..5420716 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AYR10_RS27600 5420879..5421100 - 222 WP_001220314.1 DUF987 domain-containing protein -
AYR10_RS27605 5421163..5421639 - 477 WP_001186738.1 RadC family protein -
AYR10_RS27610 5421655..5422140 - 486 WP_000214398.1 antirestriction protein -
AYR10_RS27615 5422231..5423049 - 819 WP_001234682.1 DUF945 domain-containing protein -
AYR10_RS27625 5423389..5424459 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
AYR10_RS27630 5424456..5425361 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 5411307..5422140 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T116751 WP_000854914.1 NZ_CP034801:c5420295-5419921 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T116751 NZ_CP034801:c5420295-5419921 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT116751 WP_001280954.1 NZ_CP034801:c5420716-5420342 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT116751 NZ_CP034801:c5420716-5420342 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References