Detailed information of TA system TA116713

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4768433..4768658
• Replicon: chromosome
• Accession: NZ_CP034799
• Organism: Escherichia coli strain 2009C-4687

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: A0I37_RS24030
• Protein ID: WP_000813258.1
• Coordinates: 4768503..4768658 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4768433..4768491 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A0I37_RS23980	4763500..4763741	+	242	Protein_4546	hypothetical protein	-
A0I37_RS23985	4763725..4764150	+	426	WP_000693878.1	Rha family transcriptional regulator	-
A0I37_RS23990	4764219..4765715	+	1497	WP_164848195.1	replication 14 domain protein	-
A0I37_RS24000	4765749..4766465	+	717	WP_000450627.1	DUF1627 domain-containing protein	-
A0I37_RS24005	4766498..4766779	+	282	WP_000603384.1	DNA-binding protein	-
A0I37_RS24010	4766776..4767003	+	228	WP_000699809.1	hypothetical protein	-
A0I37_RS24015	4766996..4767307	+	312	WP_001289673.1	hypothetical protein	-
A0I37_RS24020	4767435..4767653	+	219	WP_000683609.1	DUF4014 family protein	-
A0I37_RS24025	4767655..4768212	+	558	WP_000104474.1	DUF551 domain-containing protein	-
-	4768433..4768491	-	59	-	-	Antitoxin
A0I37_RS24030	4768503..4768658	+	156	WP_000813258.1	type I toxin-antitoxin system Hok family toxin	Toxin
A0I37_RS24035	4768778..4769122	+	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
A0I37_RS24040	4769244..4769516	+	273	WP_000191872.1	hypothetical protein	-
A0I37_RS24045	4769518..4770567	+	1050	WP_001265229.1	DUF968 domain-containing protein	-
A0I37_RS24050	4770580..4770885	+	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
A0I37_RS24055	4770948..4771502	+	555	WP_000640035.1	DUF1133 family protein	-
A0I37_RS24060	4771727..4771924	+	198	WP_000917763.1	hypothetical protein	-
A0I37_RS24065	4772060..4772773	+	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
A0I37_RS24080	4773224..4773655	+	432	WP_001302123.1	tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	4694922..4816796	121874

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T116713 WP_000813258.1 NZ_CP034799:4768503-4768658 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T116713 NZ_CP034799:4768503-4768658 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT116713 NZ_CP034799:c4768491-4768433 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin