Detailed information of TA system TA116695

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 2370686..2370907
• Replicon: chromosome
• Accession: NZ_CP034799
• Organism: Escherichia coli strain 2009C-4687

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: A0I37_RS11335
• Protein ID: WP_001295224.1
• Coordinates: 2370800..2370907 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2370686..2370751 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A0I37_RS11315	2366126..2367028	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
A0I37_RS11320	2367039..2368022	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
A0I37_RS11325	2368019..2369023	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
A0I37_RS11330	2369053..2370324	-	1272	WP_001301684.1	amino acid permease	-
-	2370686..2370751	-	66	NuclAT_16	-	Antitoxin
-	2370686..2370751	-	66	NuclAT_16	-	Antitoxin
-	2370686..2370751	-	66	NuclAT_16	-	Antitoxin
-	2370686..2370751	-	66	NuclAT_16	-	Antitoxin
-	2370686..2370751	-	66	NuclAT_21	-	Antitoxin
-	2370686..2370751	-	66	NuclAT_21	-	Antitoxin
-	2370686..2370751	-	66	NuclAT_21	-	Antitoxin
-	2370686..2370751	-	66	NuclAT_21	-	Antitoxin
A0I37_RS11335	2370800..2370907	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
A0I37_RS11340	2370994..2372673	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
A0I37_RS11345	2372670..2372861	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
A0I37_RS11350	2372858..2374429	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
A0I37_RS11355	2374702..2374890	+	189	WP_001063316.1	YhjR family protein	-
A0I37_RS11360	2374902..2375099	+	198	WP_000279508.1	AAA family ATPase	-
A0I37_RS11365	2375118..2375654	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T116695 WP_001295224.1 NZ_CP034799:2370800-2370907 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T116695 NZ_CP034799:2370800-2370907 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT116695 NZ_CP034799:c2370751-2370686 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin