Detailed information of TA system TA116663

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 2680248..2680469
• Replicon: chromosome
• Accession: NZ_CP034797
• Organism: Escherichia coli strain 08-3918

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: AYP37_RS14455
• Protein ID: WP_001295224.1
• Coordinates: 2680248..2680355 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	2680404..2680469 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYP37_RS14430	2675501..2676253	-	753	Protein_2642	cellulose biosynthesis protein BcsQ	-
AYP37_RS14435	2676265..2676453	-	189	WP_001063316.1	YhjR family protein	-
AYP37_RS14440	2676726..2678297	+	1572	Protein_2644	cellulose biosynthesis protein BcsE	-
AYP37_RS14445	2678294..2678485	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
AYP37_RS14450	2678482..2680161	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
AYP37_RS14455	2680248..2680355	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2680404..2680469	+	66	NuclAT_16	-	Antitoxin
-	2680404..2680469	+	66	NuclAT_16	-	Antitoxin
-	2680404..2680469	+	66	NuclAT_16	-	Antitoxin
-	2680404..2680469	+	66	NuclAT_16	-	Antitoxin
-	2680404..2680469	+	66	NuclAT_21	-	Antitoxin
-	2680404..2680469	+	66	NuclAT_21	-	Antitoxin
-	2680404..2680469	+	66	NuclAT_21	-	Antitoxin
-	2680404..2680469	+	66	NuclAT_21	-	Antitoxin
AYP37_RS14460	2680831..2682102	+	1272	WP_001301684.1	amino acid permease	-
AYP37_RS14465	2682132..2683136	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
AYP37_RS14470	2683133..2684116	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
AYP37_RS14475	2684127..2685029	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T116663 WP_001295224.1 NZ_CP034797:c2680355-2680248 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T116663 NZ_CP034797:c2680355-2680248 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT116663 NZ_CP034797:2680404-2680469 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin