Detailed information of TA system TA116630

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4180398..4180619
• Replicon: chromosome
• Accession: NZ_CP034794
• Organism: Escherichia coli strain 06-3462

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: A1D74_RS21650
• Protein ID: WP_001295224.1
• Coordinates: 4180398..4180505 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4180554..4180619 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1D74_RS21625	4175652..4176404	-	753	Protein_4095	cellulose biosynthesis protein BcsQ	-
A1D74_RS21630	4176416..4176604	-	189	WP_001063316.1	YhjR family protein	-
A1D74_RS21635	4176876..4178447	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
A1D74_RS21640	4178444..4178635	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
A1D74_RS21645	4178632..4180311	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
A1D74_RS21650	4180398..4180505	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4180554..4180619	+	66	NuclAT_16	-	Antitoxin
-	4180554..4180619	+	66	NuclAT_16	-	Antitoxin
-	4180554..4180619	+	66	NuclAT_16	-	Antitoxin
-	4180554..4180619	+	66	NuclAT_16	-	Antitoxin
-	4180554..4180619	+	66	NuclAT_21	-	Antitoxin
-	4180554..4180619	+	66	NuclAT_21	-	Antitoxin
-	4180554..4180619	+	66	NuclAT_21	-	Antitoxin
-	4180554..4180619	+	66	NuclAT_21	-	Antitoxin
A1D74_RS21655	4180981..4182252	+	1272	WP_001301684.1	amino acid permease	-
A1D74_RS21660	4182282..4183286	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
A1D74_RS21665	4183283..4184266	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
A1D74_RS21670	4184277..4185179	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T116630 WP_001295224.1 NZ_CP034794:c4180505-4180398 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T116630 NZ_CP034794:c4180505-4180398 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT116630 NZ_CP034794:4180554-4180619 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin