Detailed information of TA system TA116584

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2522844..2523069
• Replicon: chromosome
• Accession: NZ_CP034792
• Organism: Escherichia coli strain 2009C-3378

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: DR788_RS13515
• Protein ID: WP_000813263.1
• Coordinates: 2522844..2522999 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2523011..2523069 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DR788_RS13480	2518298..2519011	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
DR788_RS13485	2519149..2519345	-	197	Protein_2554	TrmB family transcriptional regulator	-
DR788_RS13490	2519632..2520450	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
DR788_RS13495	2520602..2520973	-	372	WP_000090264.1	antitermination protein	-
DR788_RS13500	2520963..2521334	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
DR788_RS13505	2521347..2522396	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
DR788_RS13510	2522398..2522676	-	279	WP_001341388.1	hypothetical protein	-
DR788_RS13515	2522844..2522999	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2523011..2523069	+	59	-	-	Antitoxin
DR788_RS13530	2523604..2524377	+	774	WP_000160654.1	alpha/beta hydrolase	-
DR788_RS13535	2524729..2525142	-	414	WP_001151233.1	DUF977 family protein	-
DR788_RS13540	2525158..2525928	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
DR788_RS13545	2525950..2526696	-	747	WP_000788745.1	ATP-binding protein	-
DR788_RS13550	2526703..2527794	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T116584 WP_000813263.1 NZ_CP034792:c2522999-2522844 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T116584 NZ_CP034792:c2522999-2522844 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT116584 NZ_CP034792:2523011-2523069 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin