Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 715180..715873 Replicon chromosome
Accession NZ_CP034784
Organism Escherichia coli strain ECZP248

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag ENE68_RS03480 Protein ID WP_000415584.1
Coordinates 715180..715476 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag ENE68_RS03485 Protein ID WP_000650107.1
Coordinates 715478..715873 (+) Length 132 a.a.

Genomic Context


ENE68_RS03450ENE68_RS24340ENE68_RS03470ENE68_RS03475ENE68_RS03480ENE68_RS03485ENE68_RS03490ENE68_RS03495ENE68_RS03460ENE68_RS03465
Location: 710737..710993 (257 bp)
Type: Others
Protein ID: Protein_679
Location: 711759..711845 (87 bp)
Type: Others
Protein ID: Protein_681
Location: 714048..714440 (393 bp)
Type: Others
Protein ID: WP_000712658.1
Location: 714493..714975 (483 bp)
Type: Others
Protein ID: WP_000183505.1
Location: 715180..715476 (297 bp)
Type: Toxin
Protein ID: WP_000415584.1
Location: 715478..715873 (396 bp)
Type: Antitoxin
Protein ID: WP_000650107.1
Location: 716006..717613 (1608 bp)
Type: Others
Protein ID: WP_001295629.1
Location: 717751..720009 (2259 bp)
Type: Others
Protein ID: WP_032161229.1
Location: 711891..713240 (1350 bp)
Type: Others
Protein ID: WP_032235163.1
Location: 713237..713896 (660 bp)
Type: Others
Protein ID: WP_001221493.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ENE68_RS03450 (710737)710737..710993+257Protein_679DUF2645 family protein-
ENE68_RS24340 (711759)711759..711845+87Protein_681DUF2645 domain-containing protein-
ENE68_RS03460 (711891)711891..713240-1350WP_032235163.1quorum sensing histidine kinase QseC-
ENE68_RS03465 (713237)713237..713896-660WP_001221493.1quorum sensing response regulator transcription factor QseB-
ENE68_RS03470 (714048)714048..714440+393WP_000712658.1OB fold stress tolerance protein YgiW-
ENE68_RS03475 (714493)714493..714975+483WP_000183505.1GyrI-like domain-containing protein-
ENE68_RS03480 (715180)715180..715476+297WP_000415584.1type II toxin-antitoxin system toxin MqsRToxin
ENE68_RS03485 (715478)715478..715873+396WP_000650107.1type II toxin-antitoxin system antitoxin MqsAAntitoxin
ENE68_RS03490 (716006)716006..717613+1608WP_001295629.1ABC transporter substrate-binding protein-
ENE68_RS03495 (717751)717751..720009+2259WP_032161229.1DNA topoisomerase IV subunit A-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--711005..711382377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T116519 WP_000415584.1 NZ_CP034784:715180-715476 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T116519 NZ_CP034784:715180-715476 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT116519 WP_000650107.1 NZ_CP034784:715478-715873 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT116519 NZ_CP034784:715478-715873 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB3HI2


Antitoxin

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Source
ID
Structure
PDB3HI2
PDB3GA8
PDB3O9X
PDB2KZ8
PDB3FMY
PDB3GN5
AlphaFold DBA0A7U9LU65

References