Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 715180..715873 | Replicon | chromosome |
Accession | NZ_CP034784 | ||
Organism | Escherichia coli strain ECZP248 |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | S1EZG2 |
Locus tag | ENE68_RS03480 | Protein ID | WP_000415584.1 |
Coordinates | 715180..715476 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | S1EBV2 |
Locus tag | ENE68_RS03485 | Protein ID | WP_000650107.1 |
Coordinates | 715478..715873 (+) | Length | 132 a.a. |
Genomic Context
Location: 710737..710993 (257 bp)
Type: Others
Protein ID: Protein_679
Type: Others
Protein ID: Protein_679
Location: 711759..711845 (87 bp)
Type: Others
Protein ID: Protein_681
Type: Others
Protein ID: Protein_681
Location: 714048..714440 (393 bp)
Type: Others
Protein ID: WP_000712658.1
Type: Others
Protein ID: WP_000712658.1
Location: 714493..714975 (483 bp)
Type: Others
Protein ID: WP_000183505.1
Type: Others
Protein ID: WP_000183505.1
Location: 715180..715476 (297 bp)
Type: Toxin
Protein ID: WP_000415584.1
Type: Toxin
Protein ID: WP_000415584.1
Location: 715478..715873 (396 bp)
Type: Antitoxin
Protein ID: WP_000650107.1
Type: Antitoxin
Protein ID: WP_000650107.1
Location: 716006..717613 (1608 bp)
Type: Others
Protein ID: WP_001295629.1
Type: Others
Protein ID: WP_001295629.1
Location: 717751..720009 (2259 bp)
Type: Others
Protein ID: WP_032161229.1
Type: Others
Protein ID: WP_032161229.1
Location: 711891..713240 (1350 bp)
Type: Others
Protein ID: WP_032235163.1
Type: Others
Protein ID: WP_032235163.1
Location: 713237..713896 (660 bp)
Type: Others
Protein ID: WP_001221493.1
Type: Others
Protein ID: WP_001221493.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ENE68_RS03450 (710737) | 710737..710993 | + | 257 | Protein_679 | DUF2645 family protein | - |
ENE68_RS24340 (711759) | 711759..711845 | + | 87 | Protein_681 | DUF2645 domain-containing protein | - |
ENE68_RS03460 (711891) | 711891..713240 | - | 1350 | WP_032235163.1 | quorum sensing histidine kinase QseC | - |
ENE68_RS03465 (713237) | 713237..713896 | - | 660 | WP_001221493.1 | quorum sensing response regulator transcription factor QseB | - |
ENE68_RS03470 (714048) | 714048..714440 | + | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
ENE68_RS03475 (714493) | 714493..714975 | + | 483 | WP_000183505.1 | GyrI-like domain-containing protein | - |
ENE68_RS03480 (715180) | 715180..715476 | + | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
ENE68_RS03485 (715478) | 715478..715873 | + | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
ENE68_RS03490 (716006) | 716006..717613 | + | 1608 | WP_001295629.1 | ABC transporter substrate-binding protein | - |
ENE68_RS03495 (717751) | 717751..720009 | + | 2259 | WP_032161229.1 | DNA topoisomerase IV subunit A | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 711005..711382 | 377 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T116519 WP_000415584.1 NZ_CP034784:715180-715476 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T116519 NZ_CP034784:715180-715476 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT116519 WP_000650107.1 NZ_CP034784:715478-715873 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT116519 NZ_CP034784:715478-715873 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA