Detailed information of TA system TA116484

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3567520..3568177
• Replicon: chromosome
• Accession: NZ_CP034769
• Organism: Enterobacter sp. N18-03635

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ELK40_RS17740
• Protein ID: WP_127732082.1
• Coordinates: 3567520..3567819 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1Z3MZ32
• Locus tag: ELK40_RS17745
• Protein ID: WP_063408808.1
• Coordinates: 3567830..3568177 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-95)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (8-86)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11734.39 Da
• Isoelectric Point: 10.1756

>T116484 WP_127732082.1 NZ_CP034769:3567520-3567819 [Enterobacter sp. N18-03635]
MISYFRDQWLEDFFLYGRSSNVIPSNLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
KEGKAEDLYLSPHKYTQHK

Nucleotide

• Length: 300 bp

>T116484 NZ_CP034769:3567520-3567819 [Enterobacter sp. N18-03635]
ATGATTAGTTATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTTTACGGCAGATCGAGCAATGTTATCCCTTCAAATCT
GGAAACAGCGCTTGCGAGAAAGCTCGATATCATCAGGGCAGCAACCTCGCACAGGGATTTGCGATCGCCACCGGGTAATA
TGTATGAAGCATTGAATCCTCCGCTGAAGGGCTATTCCTCCATCCGGGTAAACAGGCAATACAGGCTCGTATTTCGCTGG
AAAGAGGGTAAAGCAGAAGATCTGTACCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13039.98 Da
• Isoelectric Point: 7.0134

>AT116484 WP_063408808.1 NZ_CP034769:3567830-3568177 [Enterobacter sp. N18-03635]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNARTQEELSRIKTVADVMAKRKSGQPDVA

Nucleotide

• Length: 348 bp

>AT116484 NZ_CP034769:3567830-3568177 [Enterobacter sp. N18-03635]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGACGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAGCGATCTGGCGGAGATGCTCAATGTTCACCGCAACACCATCAGCGCGCTGGTCAATAACAATCGCAAGCTTA
CTGCCGATATGGCGATCAAGCTGGCAAAAGCCTTTGATACCACGATTGAATTCTGGCTGAACTTACAGCTGAACGTCGAT
ATCTGGGAAGCGCAATCTAACGCCAGGACGCAGGAGGAACTAAGCCGTATAAAGACCGTTGCGGACGTCATGGCTAAGCG
AAAATCTGGCCAACCGGATGTAGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z3MZ32