116382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4495596..4496170 Replicon chromosome
Accession NZ_CP034683
Organism Rheinheimera sp. LHK132

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EK374_RS20055 Protein ID WP_127026609.1
Coordinates 4495892..4496170 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EK374_RS20050 Protein ID WP_127026287.1
Coordinates 4495596..4495892 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK374_RS20025 4490709..4492151 - 1443 WP_164731925.1 amidohydrolase family protein -
EK374_RS20030 4492418..4492654 + 237 WP_127026284.1 DUF465 domain-containing protein -
EK374_RS20040 4493241..4494782 + 1542 WP_127026285.1 alpha-N-arabinofuranosidase -
EK374_RS20045 4494841..4495338 - 498 WP_127026286.1 DUF1993 family protein -
EK374_RS20050 4495596..4495892 - 297 WP_127026287.1 HigA family addiction module antidote protein Antitoxin
EK374_RS20055 4495892..4496170 - 279 WP_127026609.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EK374_RS20060 4496330..4496728 + 399 WP_127026288.1 BlaI/MecI/CopY family transcriptional regulator -
EK374_RS20065 4496730..4498112 + 1383 WP_164731926.1 peptidoglycan DD-metalloendopeptidase family protein -
EK374_RS20070 4498123..4499250 + 1128 WP_127026290.1 serine hydrolase -
EK374_RS20075 4499267..4500166 + 900 WP_127026291.1 alpha/beta hydrolase -
EK374_RS20080 4500235..4500699 + 465 WP_127026292.1 DUF4920 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10716.16 Da        Isoelectric Point: 9.9488

>T116382 WP_127026609.1 NZ_CP034683:c4496170-4495892 [Rheinheimera sp. LHK132]
MIKNFKHKGLERFYKTGSTAGIQAKHQNRLRLILSNLDQAQAIDDMDLPGLRLHELSGDRKSIWSVTVNGNWRVTFRFIG
RDAEIVNYEDYH

Download         Length: 279 bp

>T116382 NZ_CP034683:c4496170-4495892 [Rheinheimera sp. LHK132]
ATGATTAAGAACTTTAAACATAAAGGTCTTGAGCGCTTCTATAAAACAGGCAGTACGGCTGGCATACAGGCCAAGCATCA
GAATCGCCTGAGACTTATCCTGTCAAACCTTGATCAGGCACAAGCCATAGATGATATGGATCTGCCTGGCCTTCGGCTGC
ATGAACTTTCGGGTGACCGAAAAAGTATTTGGTCTGTTACTGTGAATGGAAATTGGCGTGTCACATTCAGATTTATTGGC
CGGGATGCTGAAATTGTTAACTACGAGGATTATCACTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11113.98 Da        Isoelectric Point: 7.4019

>AT116382 WP_127026287.1 NZ_CP034683:c4495892-4495596 [Rheinheimera sp. LHK132]
MSMHNPAHPGEILKELIIEPLALTVTDVSAHLNISRKTLSKVLNAKGAITPEMALRLELAFSKPSAEHWLRLQNAYDLWL
VREQQSELQVLPYQLKFA

Download         Length: 297 bp

>AT116382 NZ_CP034683:c4495892-4495596 [Rheinheimera sp. LHK132]
ATGAGTATGCATAACCCGGCTCACCCTGGTGAGATTCTAAAAGAGCTGATTATTGAGCCTTTGGCTTTAACCGTGACTGA
TGTTTCAGCGCATTTGAATATCAGCCGTAAAACCTTGTCCAAAGTACTGAATGCCAAAGGTGCTATTACACCGGAAATGG
CACTGCGTCTGGAACTGGCATTTAGTAAACCTTCGGCTGAGCATTGGCTCCGGTTACAAAACGCCTACGATCTGTGGCTG
GTGCGTGAGCAACAATCGGAGTTACAGGTGTTGCCTTATCAGTTGAAATTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References