Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3673227..3673824 Replicon chromosome
Accession NZ_CP034678
Organism Klebsiella quasipneumoniae strain D120-1

Toxin (Protein)


Gene name higB Uniprot ID A0A3T0QUS6
Locus tag ELE18_RS18950 Protein ID WP_017899012.1
Coordinates 3673507..3673824 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T0QUV3
Locus tag ELE18_RS18945 Protein ID WP_017899013.1
Coordinates 3673227..3673514 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELE18_RS18915 3669314..3669562 + 249 WP_002893037.1 DUF1158 domain-containing protein -
ELE18_RS18920 3669580..3669921 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
ELE18_RS18925 3669952..3671067 - 1116 WP_025999133.1 MBL fold metallo-hydrolase -
ELE18_RS18930 3671247..3671828 + 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
ELE18_RS18935 3671828..3672196 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
ELE18_RS18940 3672316..3672969 + 654 WP_004202485.1 oxygen-insensitive NAD(P)H nitroreductase -
ELE18_RS18945 3673227..3673514 - 288 WP_017899013.1 helix-turn-helix transcriptional regulator Antitoxin
ELE18_RS18950 3673507..3673824 - 318 WP_017899012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELE18_RS18955 3674009..3675052 - 1044 WP_094334190.1 DUF2157 domain-containing protein -
ELE18_RS18965 3675585..3676454 - 870 WP_017900842.1 helix-turn-helix transcriptional regulator -
ELE18_RS18970 3676563..3677990 + 1428 WP_127113759.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12185.52 Da        Isoelectric Point: 11.2767

>T116374 WP_017899012.1 NZ_CP034678:c3673824-3673507 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKTPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T116374 NZ_CP034678:c3673824-3673507 [Klebsiella quasipneumoniae]
ATGTTCAGAATGGTTGTGCATGTGGACGTTAAAAAGGAGTTGCAGGCGCTTCCGGCTATTGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTTGGACAAGGGCTATTTGAAA
TTCGAGCGTTAGGTTCGGTACAGGGGCGGGGGATCTACGTTTTTCAGCAAAACAAAACGCTCTTTCTGCTACGTGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTTATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.52 Da        Isoelectric Point: 10.2213

>AT116374 WP_017899013.1 NZ_CP034678:c3673514-3673227 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT116374 NZ_CP034678:c3673514-3673227 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAGCACCGATTACGTACTATGCTGGCACAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTTGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCACCAGCCTGGATACCTTAACGCGA
TACGCGTTAGCGTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0QUS6

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0QUV3

References