Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3860551..3861053 Replicon chromosome
Accession NZ_CP034668
Organism Proteus vulgaris strain PvSC3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EKQ45_RS20055 Protein ID WP_075671248.1
Coordinates 3860799..3861053 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag EKQ45_RS20050 Protein ID WP_072068851.1
Coordinates 3860551..3860802 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKQ45_RS20025 3856142..3856918 + 777 WP_006534565.1 phosphate ABC transporter ATP-binding protein PstB -
EKQ45_RS20030 3856933..3857667 + 735 WP_075671254.1 phosphate signaling complex protein PhoU -
EKQ45_RS20035 3857883..3858722 + 840 WP_036933789.1 ABC transporter substrate-binding protein -
EKQ45_RS20040 3858829..3859566 + 738 WP_191901648.1 amino acid ABC transporter permease -
EKQ45_RS20045 3859568..3860320 + 753 WP_191901649.1 amino acid ABC transporter permease -
EKQ45_RS20050 3860551..3860802 + 252 WP_072068851.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EKQ45_RS20055 3860799..3861053 + 255 WP_075671248.1 Txe/YoeB family addiction module toxin Toxin
EKQ45_RS20060 3861210..3862568 + 1359 WP_075671246.1 NCS2 family permease -
EKQ45_RS20065 3862649..3862960 + 312 WP_098941657.1 monooxygenase -
EKQ45_RS20070 3863010..3863558 - 549 WP_075671242.1 GNAT family N-acetyltransferase -
EKQ45_RS20075 3863561..3865033 - 1473 WP_191901650.1 glycosyltransferase family 39 protein -
EKQ45_RS20080 3865222..3865719 + 498 WP_075671238.1 Der GTPase-activating protein YihI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10170.78 Da        Isoelectric Point: 9.9411

>T116352 WP_075671248.1 NZ_CP034668:3860799-3861053 [Proteus vulgaris]
MKLIFSEQSWSDYLYWQQIDKKIIKRINELIKDIKRTPFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDSAIEIASC
RYHY

Download         Length: 255 bp

>T116352 NZ_CP034668:3860799-3861053 [Proteus vulgaris]
ATGAAATTAATTTTTTCTGAGCAATCATGGAGTGATTATCTTTATTGGCAACAAATAGACAAGAAAATAATTAAACGCAT
TAACGAACTCATAAAAGATATTAAAAGAACACCGTTTAGCGGAATAGGTAAACCAGAGCCCTTGAAACATAATTTAGCAG
GTTTTTGGTCAAGACGGATCACTGATGAACATCGCCTTATCTACCGTATTACTGATTCCGCTATAGAAATTGCATCATGT
CGATACCACTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.77 Da        Isoelectric Point: 4.4354

>AT116352 WP_072068851.1 NZ_CP034668:3860551-3860802 [Proteus vulgaris]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Download         Length: 252 bp

>AT116352 NZ_CP034668:3860551-3860802 [Proteus vulgaris]
ATGAAAACGATAAATTATACAGAAGCAAGACAAAACTTAACTTCAATTATGAATGAAACAATTGATGATAGAGTACCCAT
CATGATCACAAGGCAAAAGGGTATTCCATGTGTTCTTTTATCTCTTGATGAATACCAAGCACTAGAAGAAACTGCCTATC
TGTTACGATCTCCAGCGAATGCGCGCCATTTGCTCGATTCTATTGATGAACTGAACCAAGGTAAAGGTATAGAAAAGGAT
ATAACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References