Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2056342..2056844 | Replicon | chromosome |
| Accession | NZ_CP034658 | ||
| Organism | Escherichia coli strain ATCC 98082 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | EKH78_RS10130 | Protein ID | WP_000767829.1 |
| Coordinates | 2056342..2056596 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | EKH78_RS10135 | Protein ID | WP_001259255.1 |
| Coordinates | 2056593..2056844 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EKH78_RS10100 (2051357) | 2051357..2051584 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
| EKH78_RS10105 (2051598) | 2051598..2052656 | - | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| EKH78_RS10110 (2052835) | 2052835..2054193 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| EKH78_RS10115 (2054183) | 2054183..2054245 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| EKH78_RS10120 (2054460) | 2054460..2055389 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| EKH78_RS10125 (2055435) | 2055435..2056259 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| EKH78_RS10130 (2056342) | 2056342..2056596 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| EKH78_RS10135 (2056593) | 2056593..2056844 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| EKH78_RS10140 (2057127) | 2057127..2057177 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| EKH78_RS10145 (2057323) | 2057323..2058222 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| EKH78_RS10150 (2058228) | 2058228..2059532 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| EKH78_RS10155 (2059529) | 2059529..2060599 | + | 1071 | WP_000108942.1 | histidinol-phosphate transaminase | - |
| EKH78_RS10160 (2060599) | 2060599..2061666 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T116324 WP_000767829.1 NZ_CP034658:c2056596-2056342 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T116324 NZ_CP034658:c2056596-2056342 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT116324 WP_001259255.1 NZ_CP034658:c2056844-2056593 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT116324 NZ_CP034658:c2056844-2056593 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|