Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3965957..3966650 Replicon chromosome
Accession NZ_CP034589
Organism Escherichia coli strain L37

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EKM58_RS19300 Protein ID WP_000415584.1
Coordinates 3966354..3966650 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EKM58_RS19295 Protein ID WP_000650107.1
Coordinates 3965957..3966352 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKM58_RS19285 3961821..3964079 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
EKM58_RS19290 3964217..3965824 - 1608 WP_106631741.1 ABC transporter substrate-binding protein -
EKM58_RS19295 3965957..3966352 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EKM58_RS19300 3966354..3966650 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EKM58_RS19305 3966855..3967337 - 483 WP_000183505.1 transcriptional regulator -
EKM58_RS19310 3967390..3967782 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EKM58_RS19315 3967934..3968593 + 660 WP_001221493.1 two-component system response regulator QseB -
EKM58_RS19320 3968590..3969939 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
EKM58_RS19325 3969985..3970317 - 333 WP_000917684.1 DUF2645 family protein -
EKM58_RS19330 3970636..3971217 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EKM58_RS19335 3971248..3971562 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T116248 WP_000415584.1 NZ_CP034589:c3966650-3966354 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T116248 NZ_CP034589:c3966650-3966354 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT116248 WP_000650107.1 NZ_CP034589:c3966352-3965957 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT116248 NZ_CP034589:c3966352-3965957 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References