Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3210442..3211057 Replicon chromosome
Accession NZ_CP034554
Organism Burkholderia cepacia ATCC 25416

Toxin (Protein)


Gene name higB Uniprot ID A0A806VP16
Locus tag EJ998_RS33230 Protein ID WP_027789973.1
Coordinates 3210442..3210783 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A806UZQ0
Locus tag EJ998_RS33235 Protein ID WP_027789974.1
Coordinates 3210770..3211057 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ998_RS33220 3207527..3209164 - 1638 WP_027789971.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
EJ998_RS33225 3209594..3210226 + 633 WP_027789972.1 LysE family translocator -
EJ998_RS33230 3210442..3210783 + 342 WP_027789973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJ998_RS33235 3210770..3211057 + 288 WP_027789974.1 helix-turn-helix transcriptional regulator Antitoxin
EJ998_RS33240 3211137..3211826 - 690 WP_027789975.1 YebB family permuted papain-like enzyme -
EJ998_RS33245 3212006..3212575 - 570 WP_027789976.1 hypothetical protein -
EJ998_RS33250 3212796..3213254 - 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
EJ998_RS33255 3213381..3214115 + 735 WP_027789977.1 AzlC family ABC transporter permease -
EJ998_RS33260 3214108..3214416 + 309 WP_027789978.1 AzlD family protein -
EJ998_RS33265 3214735..3215514 + 780 WP_027789979.1 5'/3'-nucleotidase SurE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13112.25 Da        Isoelectric Point: 9.5171

>T116220 WP_027789973.1 NZ_CP034554:3210442-3210783 [Burkholderia cepacia ATCC 25416]
MRTVADEIHFFSEQVEAGVFALPKTLIARFFALADRMEQYGPNPGEPHTRPMGDGLYEMRLKGLEDIARVFYCAVVNRRI
VMLHCYVKKTQKTPQKDLETARRRLKEIRDGNL

Download         Length: 342 bp

>T116220 NZ_CP034554:3210442-3210783 [Burkholderia cepacia ATCC 25416]
ATGCGAACCGTCGCGGATGAAATCCATTTCTTCAGCGAGCAAGTCGAGGCTGGCGTATTTGCGTTGCCGAAAACGCTGAT
CGCCAGATTCTTCGCACTCGCTGACCGCATGGAGCAGTACGGCCCGAATCCGGGCGAACCTCACACCAGGCCGATGGGCG
ACGGGTTGTACGAAATGCGGTTGAAGGGCCTGGAAGATATCGCACGTGTGTTTTACTGCGCGGTCGTCAACCGGCGGATC
GTCATGCTTCACTGCTACGTGAAGAAGACGCAGAAAACGCCGCAGAAGGACCTGGAAACCGCGCGCCGCCGATTGAAGGA
GATTCGAGATGGCAACCTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10296.90 Da        Isoelectric Point: 9.6540

>AT116220 WP_027789974.1 NZ_CP034554:3210770-3211057 [Burkholderia cepacia ATCC 25416]
MATYKALRERALADPTVCAEYDRLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIDTLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT116220 NZ_CP034554:3210770-3211057 [Burkholderia cepacia ATCC 25416]
ATGGCAACCTATAAGGCACTGCGCGAGCGCGCGTTGGCCGATCCGACGGTATGCGCCGAGTACGACCGGCTGAACCGCGA
GGAATTCGCGCTGCTCGACGCAATGCTGGCCGCCCGGCGAGCCGCCGGTCTTTCGCAAGCCGATGTGGCAGAGCGCATGG
GCACGAAGGCGCCTGCCGTCACGCGGCTCGAACGTGCGCTCGCGACAGGCCAGCACTCGCCGTCGATTGATACGCTGCGC
AAGTATGCGGCCGCATGCGGCAAGAAACTCGTGATCTCTTTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806VP16

Antitoxin

Source ID Structure
AlphaFold DB A0A806UZQ0

References