Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1984028..1984728 Replicon chromosome
Accession NZ_CP034554
Organism Burkholderia cepacia ATCC 25416

Toxin (Protein)


Gene name mqsR Uniprot ID A0A806V3J0
Locus tag EJ998_RS27510 Protein ID WP_027791640.1
Coordinates 1984028..1984324 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A806V1K0
Locus tag EJ998_RS27515 Protein ID WP_027791641.1
Coordinates 1984327..1984728 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ998_RS27495 1980560..1982110 + 1551 WP_027791637.1 sensor domain-containing diguanylate cyclase -
EJ998_RS27500 1982354..1982629 + 276 WP_027791638.1 hypothetical protein -
EJ998_RS27505 1982884..1983924 + 1041 WP_027791639.1 succinylglutamate desuccinylase/aspartoacylase family protein -
EJ998_RS27510 1984028..1984324 + 297 WP_027791640.1 type II toxin-antitoxin system MqsR family toxin Toxin
EJ998_RS27515 1984327..1984728 + 402 WP_027791641.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EJ998_RS27520 1985046..1985606 + 561 WP_027791642.1 GNAT family N-acetyltransferase -
EJ998_RS27525 1985663..1986616 + 954 WP_027791643.1 ABC transporter substrate-binding protein -
EJ998_RS27530 1986680..1987729 + 1050 WP_027791644.1 LLM class flavin-dependent oxidoreductase -
EJ998_RS27535 1987737..1989089 + 1353 WP_027791645.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11203.05 Da        Isoelectric Point: 8.0535

>T116216 WP_027791640.1 NZ_CP034554:1984028-1984324 [Burkholderia cepacia ATCC 25416]
MEKRRPHCKLPLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T116216 NZ_CP034554:1984028-1984324 [Burkholderia cepacia ATCC 25416]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGCCCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAGCTGGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14549.82 Da        Isoelectric Point: 8.8305

>AT116216 WP_027791641.1 NZ_CP034554:1984327-1984728 [Burkholderia cepacia ATCC 25416]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRAVTGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT116216 NZ_CP034554:1984327-1984728 [Burkholderia cepacia ATCC 25416]
ATGAAGTGTCCTGCATGCGGTGCTGCGAAGCTCGTCCGCGACACGCGCGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGCTGTCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTGCTGGATCTCGACGAAGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTGCGCAAGAAG
CTGAAGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCATCCCGATCTGCTCGCCGAAGTCCGGGCCGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806V3J0

Antitoxin

Source ID Structure
AlphaFold DB A0A806V1K0

References