Detailed information of TA system TA116200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1209611..1210226
• Replicon: chromosome
• Accession: NZ_CP034547
• Organism: Burkholderia cenocepacia strain YG-3

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: D5R55_RS29065
• Protein ID: WP_126368134.1
• Coordinates: 1209611..1209952 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D5R55_RS29070
• Protein ID: WP_126368137.1
• Coordinates: 1209939..1210226 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R55_RS29030	1205427..1205846	-	420	WP_126368122.1	secondary thiamine-phosphate synthase enzyme YjbQ	-
D5R55_RS29035	1205857..1206183	-	327	WP_126368124.1	thioredoxin family protein	-
D5R55_RS29040	1206395..1207099	+	705	WP_126368126.1	flavin reductase family protein	-
D5R55_RS29045	1207098..1207259	+	162	Protein_1045	MFS transporter	-
D5R55_RS29050	1207313..1207645	+	333	WP_126368128.1	DUF2322 family protein	-
D5R55_RS29055	1207752..1208621	+	870	WP_126368130.1	PASTA domain-containing protein	-
D5R55_RS29060	1208764..1209396	+	633	WP_126368132.1	LysE family translocator	-
D5R55_RS29065	1209611..1209952	+	342	WP_126368134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5R55_RS29070	1209939..1210226	+	288	WP_126368137.1	helix-turn-helix domain-containing protein	Antitoxin
D5R55_RS29075	1210321..1210995	-	675	WP_126368139.1	YebB family permuted papain-like enzyme	-
D5R55_RS29080	1211144..1211713	-	570	WP_126368141.1	hypothetical protein	-
D5R55_RS29085	1211940..1212398	-	459	WP_006486309.1	Lrp/AsnC family transcriptional regulator	-
D5R55_RS29090	1212524..1213258	+	735	WP_126368143.1	AzlC family ABC transporter permease	-
D5R55_RS29095	1213251..1213559	+	309	WP_126368145.1	AzlD family protein	-
D5R55_RS29100	1213751..1214530	+	780	WP_126368147.1	5'/3'-nucleotidase SurE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (21-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-90)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12998.20 Da
• Isoelectric Point: 10.1309

>T116200 WP_126368134.1 NZ_CP034547:1209611-1209952 [Burkholderia cenocepacia]
MATHGYEIQFFNERVALGVASLPTTLLARYFALADRMERYGPNLGEPHSRSMGNGLYEMRLKGVEGIARVFYCAIVERRI
VMPHCYVKKTPRTPLKELEIARRRLKEVRDGNV

Nucleotide

• Length: 342 bp

>T116200 NZ_CP034547:1209611-1209952 [Burkholderia cenocepacia]
ATGGCAACTCATGGTTACGAGATCCAGTTCTTCAATGAGCGTGTAGCGCTGGGCGTCGCGTCGTTGCCGACTACCCTGCT
CGCCCGGTACTTTGCCCTGGCTGACCGCATGGAACGGTACGGCCCGAATCTCGGGGAGCCCCACTCCCGATCGATGGGAA
ACGGCCTGTACGAAATGCGATTGAAAGGCGTGGAAGGGATTGCCCGAGTGTTTTACTGCGCGATCGTCGAGCGGCGTATC
GTCATGCCCCACTGCTACGTGAAGAAAACGCCCAGGACGCCGCTGAAGGAACTGGAAATCGCGCGTCGTCGATTGAAGGA
GGTTCGGGATGGCAACGTATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10438.99 Da
• Isoelectric Point: 9.6538

>AT116200 WP_126368137.1 NZ_CP034547:1209939-1210226 [Burkholderia cenocepacia]
MATYKELRERALADPAVRTEYERLNREEFALLDAMLAARREAGLSQADVATRMGTKAPAITRLERALATGQHSPSIDTLR
KYAAACGKTLVISFA

Nucleotide

• Length: 288 bp

>AT116200 NZ_CP034547:1209939-1210226 [Burkholderia cenocepacia]
ATGGCAACGTATAAGGAACTACGCGAGCGGGCATTGGCCGACCCCGCCGTGCGTACGGAATACGAGCGATTGAATCGCGA
GGAATTCGCGCTGCTCGACGCGATGCTGGCGGCACGGCGAGAGGCTGGCTTGTCGCAAGCCGATGTGGCGACACGCATGG
GCACGAAAGCGCCCGCCATTACGCGACTCGAGCGCGCGCTCGCAACCGGCCAGCATTCCCCGTCCATCGATACGCTGCGC
AAGTATGCGGCGGCTTGCGGCAAGACGCTCGTGATCTCGTTCGCCTGA