Detailed information of TA system TA116194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 137645..138158
• Replicon: chromosome
• Accession: NZ_CP034543
• Organism: Streptococcus periodonticum strain KCOM 2412

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: I0SIM6
• Locus tag: EHW89_RS00795
• Protein ID: WP_003034719.1
• Coordinates: 137645..137899 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EHW89_RS00800
• Protein ID: WP_126466411.1
• Coordinates: 137892..138158 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHW89_RS00760	133522..133938	-	417	WP_126466407.1	conjugal transfer protein	-
EHW89_RS00765	133940..134167	-	228	WP_126466408.1	hypothetical protein	-
EHW89_RS00770	134184..135176	-	993	WP_126466409.1	conjugal transfer protein	-
EHW89_RS00775	135186..135740	-	555	WP_049533170.1	hypothetical protein	-
EHW89_RS00780	135737..135973	-	237	WP_000456039.1	hypothetical protein	-
EHW89_RS00785	135994..136380	-	387	WP_126468021.1	hypothetical protein	-
EHW89_RS00790	136358..137590	-	1233	WP_126466410.1	replication initiation factor domain-containing protein	-
EHW89_RS00795	137645..137899	-	255	WP_003034719.1	Txe/YoeB family addiction module toxin	Toxin
EHW89_RS00800	137892..138158	-	267	WP_126466411.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EHW89_RS00805	138674..140071	+	1398	WP_126466412.1	MucBP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10509.97 Da
• Isoelectric Point: 9.2761

>T116194 WP_003034719.1 NZ_CP034543:c137899-137645 [Streptococcus periodonticum]
MFNFTEQAWKDYVSWQQEDKKILKRINRLMEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEHRLVYMVEENEIYFLSFR
DHYK

Nucleotide

• Length: 255 bp

>T116194 NZ_CP034543:c137899-137645 [Streptococcus periodonticum]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAAGATAAAAAGATACTCAAACGGATCAA
TCGTTTAATGGAGGATATCAAACGAAATCCTTTTGAAGGGATTGGAAAGCCTGAACCCTTAAAATACCGTTATTCCGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGATTAGTCTATATGGTGGAAGAAAATGAGATTTATTTCTTATCCTTTCGA
GACCACTATAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10419.00 Da
• Isoelectric Point: 5.1617

>AT116194 WP_126466411.1 NZ_CP034543:c138158-137892 [Streptococcus periodonticum]
MEAVVYSNFRNNLKNYMKKVNDEYEPLMVVNKNPDENIVVLSKKNWDSIQETIRLMNNEYLSDKVLSGMEQVKQKKVIQR
PLLEVEDV

Nucleotide

• Length: 267 bp

>AT116194 NZ_CP034543:c138158-137892 [Streptococcus periodonticum]
ATGGAAGCTGTCGTCTATTCAAATTTTAGAAACAATTTAAAGAATTACATGAAAAAAGTCAACGATGAATATGAACCTCT
AATGGTTGTCAATAAAAATCCTGATGAAAATATTGTAGTCTTATCTAAGAAAAACTGGGATAGTATCCAAGAAACCATTC
GTCTAATGAATAACGAGTACCTTTCAGACAAGGTTCTATCAGGAATGGAACAAGTCAAGCAAAAGAAAGTCATTCAACGC
CCATTATTAGAGGTGGAAGATGTTTAA

Structures

Toxin

• AlphaFold DB: I0SIM6