Detailed information of TA system TA116182

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1240864..1241046
• Replicon: chromosome
• Accession: NZ_CP034486
• Organism: Staphylococcus aureus strain PMB 64-1

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: EJN87_RS06230
• Protein ID: WP_001801861.1
• Coordinates: 1240864..1240959 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1240987..1241046 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJN87_RS06180	1236534..1237160	+	627	WP_000669017.1	hypothetical protein	-
EJN87_RS06185	1237201..1237542	+	342	WP_000627541.1	DUF3969 family protein	-
EJN87_RS06190	1237643..1238215	+	573	WP_000414202.1	hypothetical protein	-
EJN87_RS06195	1238413..1238970	-	558	Protein_1177	ImmA/IrrE family metallo-endopeptidase	-
EJN87_RS06205	1239344..1239520	-	177	WP_000375477.1	hypothetical protein	-
EJN87_RS06210	1239531..1239914	-	384	WP_000070811.1	hypothetical protein	-
EJN87_RS06220	1240518..1240661	-	144	WP_001549059.1	transposase	-
EJN87_RS06230	1240864..1240959	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1240987..1241046	-	60	-	-	Antitoxin
EJN87_RS06235	1241082..1241183	+	102	WP_001791893.1	hypothetical protein	-
EJN87_RS06240	1241161..1241337	-	177	Protein_1183	transposase	-
EJN87_RS06245	1241531..1241908	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1217168..1306089	88921

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T116182 WP_001801861.1 NZ_CP034486:1240864-1240959 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T116182 NZ_CP034486:1240864-1240959 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT116182 NZ_CP034486:c1241046-1240987 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin