Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 88536..89363 Replicon chromosome
Accession NZ_CP034483
Organism Rahnella aquatilis strain KM05

Toxin (Protein)


Gene name yhaV Uniprot ID H8NM45
Locus tag EJP80_RS00415 Protein ID WP_014411451.1
Coordinates 88536..89012 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0H3F4N7
Locus tag EJP80_RS00420 Protein ID WP_013573435.1
Coordinates 89019..89363 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJP80_RS00390 83774..85219 + 1446 WP_119261072.1 alpha/beta hydrolase -
EJP80_RS00395 85290..85748 + 459 WP_013573431.1 MarR family transcriptional regulator -
EJP80_RS00400 85883..86305 + 423 WP_013573432.1 organic hydroperoxide resistance protein -
EJP80_RS00405 86577..88256 + 1680 WP_013573433.1 kdo(2)-lipid A phosphoethanolamine 7''-transferase -
EJP80_RS00415 88536..89012 - 477 WP_014411451.1 type II toxin-antitoxin system YhaV family toxin Toxin
EJP80_RS00420 89019..89363 - 345 WP_013573435.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
EJP80_RS00425 89445..89606 - 162 WP_071882947.1 type II toxin-antitoxin system RelE/ParE family toxin -
EJP80_RS00430 89747..91126 - 1380 WP_013573436.1 MmgE/PrpD family protein -
EJP80_RS00435 91146..91928 - 783 WP_014411455.1 ABC transporter ATP-binding protein -
EJP80_RS00440 91928..92794 - 867 WP_014411456.1 ABC transporter ATP-binding protein -
EJP80_RS00445 92787..93722 - 936 WP_119261073.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(13-148)

Antitoxin

SpoVT-AbrB domain

(15-53)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18482.31 Da        Isoelectric Point: 9.9550

>T116150 WP_014411451.1 NZ_CP034483:c89012-88536 [Rahnella aquatilis]
MHNQAMEINGWTLLAHPLILQQIQALTDQVVLLRRKDPAGYKSKNATKRLAAINKLMFDVIPQDPARVEFRQGDTLGGEF
SHWFRAKFFQQYRLFFRYNLKSRIIIYAWVNDDKELRAYESKTDAYRMFRKMLKSGEPPDNWQALCEASGKVAAEELP

Download         Length: 477 bp

>T116150 NZ_CP034483:c89012-88536 [Rahnella aquatilis]
ATGCACAATCAGGCCATGGAGATTAACGGATGGACCCTTCTCGCTCATCCTCTGATCCTGCAACAAATACAGGCACTCAC
TGATCAGGTTGTTTTACTGCGCCGCAAAGATCCGGCAGGCTATAAAAGTAAGAACGCCACCAAACGGCTGGCTGCGATCA
ATAAGCTGATGTTTGACGTTATCCCGCAGGATCCGGCGCGTGTTGAATTCCGTCAGGGCGATACGTTAGGCGGGGAATTC
TCACACTGGTTCAGGGCAAAATTCTTCCAGCAGTACCGTTTGTTTTTCCGCTACAATCTGAAAAGCCGGATCATTATTTA
CGCCTGGGTGAATGATGATAAAGAATTACGCGCCTACGAAAGCAAAACAGACGCATACCGGATGTTTCGCAAGATGTTGA
AAAGCGGTGAACCGCCAGACAACTGGCAGGCACTTTGCGAGGCGTCAGGGAAGGTAGCGGCGGAAGAATTACCTTAG

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12701.48 Da        Isoelectric Point: 4.3324

>AT116150 WP_013573435.1 NZ_CP034483:c89363-89019 [Rahnella aquatilis]
MSASALWGIKFEAESKVTRRFQTTIPATIRKALNLTENDRIQYKILPDGQVVISRQLEEAEDPVISAFLGFVAKDMLNNP
ENMQPVTLSLHEKINVLTAGMAIDLESPLSDDDE

Download         Length: 345 bp

>AT116150 NZ_CP034483:c89363-89019 [Rahnella aquatilis]
ATGTCAGCCTCGGCACTATGGGGAATAAAATTCGAAGCCGAATCCAAAGTCACCCGCCGCTTCCAGACCACCATTCCGGC
CACTATCCGTAAGGCATTAAATCTCACCGAAAATGATCGGATCCAGTACAAGATTTTGCCAGACGGGCAGGTGGTTATTT
CGAGGCAACTCGAAGAAGCGGAAGACCCTGTTATCAGTGCTTTTCTCGGTTTTGTGGCAAAAGATATGCTCAATAACCCG
GAAAATATGCAGCCGGTAACATTATCCCTGCATGAAAAAATCAATGTACTGACCGCCGGGATGGCTATCGATCTTGAGAG
CCCGCTTTCTGACGATGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H8NM45

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3F4N7

References