Detailed information of TA system TA116119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 88910..89740
• Replicon: chromosome
• Accession: NZ_CP034481
• Organism: Rahnella aquatilis strain KM25

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: EJP79_RS00425
• Protein ID: WP_126124564.1
• Coordinates: 88910..89389 (-)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: A0A0H3F4N7
• Locus tag: EJP79_RS00430
• Protein ID: WP_013573435.1
• Coordinates: 89396..89740 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP79_RS00400	84195..85640	+	1446	WP_112151980.1	alpha/beta hydrolase	-
EJP79_RS00405	85711..86169	+	459	WP_013573431.1	MarR family transcriptional regulator	-
EJP79_RS00410	86304..86726	+	423	WP_013573432.1	organic hydroperoxide resistance protein	-
EJP79_RS00415	86998..88677	+	1680	WP_013573433.1	kdo(2)-lipid A phosphoethanolamine 7''-transferase	-
EJP79_RS00425	88910..89389	-	480	WP_126124564.1	type II toxin-antitoxin system YhaV family toxin	Toxin
EJP79_RS00430	89396..89740	-	345	WP_013573435.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
EJP79_RS00435	89822..89983	-	162	WP_071882947.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EJP79_RS00440	90124..91503	-	1380	WP_013573436.1	MmgE/PrpD family protein	-
EJP79_RS00445	91523..92305	-	783	WP_014411455.1	ABC transporter ATP-binding protein	-
EJP79_RS00450	92305..93171	-	867	WP_014411456.1	ABC transporter ATP-binding protein	-
EJP79_RS00455	93164..94099	-	936	WP_112197519.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (13-148)

Antitoxin

• SpoVT-AbrB domain (15-53)

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 18699.55 Da
• Isoelectric Point: 9.9550

>T116119 WP_126124564.1 NZ_CP034481:c89389-88910 [Rahnella aquatilis]
MHNQAMEINGWTLLAHPLILQQIQALTDQVVLLRRKDPAGYKSKNATKRLAAINKLMFDVIPQDPARVEFRQGDTLGGEF
SHWFRAKFFQQYRLFFRYNLKSRIIIYAWVNDDKELRAYESKTDAYRMFRKMLKSGEPPDNWQALCEASGKIMAQEEQP

Nucleotide

• Length: 480 bp

>T116119 NZ_CP034481:c89389-88910 [Rahnella aquatilis]
ATGCACAATCAGGCCATGGAGATTAACGGATGGACCCTTCTCGCTCATCCTCTGATCCTGCAACAAATACAGGCACTCAC
TGATCAGGTTGTTTTACTGCGCCGCAAAGATCCGGCGGGCTATAAAAGTAAAAATGCCACCAAACGGCTGGCTGCGATCA
ATAAGCTGATGTTTGACGTTATCCCGCAGGATCCGGCGCGTGTTGAATTCCGTCAGGGCGATACGTTAGGCGGGGAATTC
TCACACTGGTTCAGGGCAAAATTCTTCCAGCAGTACCGTTTGTTTTTCCGCTACAACCTGAAAAGCCGGATCATTATTTA
CGCCTGGGTGAATGATGATAAAGAATTACGCGCCTACGAAAGCAAAACAGACGCATACCGGATGTTTCGCAAGATGTTGA
AAAGCGGTGAACCGCCAGACAACTGGCAGGCACTTTGCGAGGCGTCAGGGAAAATAATGGCTCAGGAAGAACAGCCGTAG

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12701.48 Da
• Isoelectric Point: 4.3324

>AT116119 WP_013573435.1 NZ_CP034481:c89740-89396 [Rahnella aquatilis]
MSASALWGIKFEAESKVTRRFQTTIPATIRKALNLTENDRIQYKILPDGQVVISRQLEEAEDPVISAFLGFVAKDMLNNP
ENMQPVTLSLHEKINVLTAGMAIDLESPLSDDDE

Nucleotide

• Length: 345 bp

>AT116119 NZ_CP034481:c89740-89396 [Rahnella aquatilis]
ATGTCAGCCTCGGCACTATGGGGAATAAAATTCGAAGCCGAATCCAAAGTCACCCGCCGCTTCCAGACCACCATTCCGGC
CACTATCCGTAAGGCATTAAATCTCACCGAAAATGATCGGATCCAGTACAAGATTTTGCCAGACGGGCAGGTGGTTATTT
CGAGGCAACTCGAAGAAGCGGAAGACCCTGTTATCAGTGCTTTTCTCGGTTTTGTGGCAAAAGATATGCTCAATAACCCG
GAAAATATGCAGCCGGTAACATTATCCCTGCATGAAAAAATCAATGTACTGACCGCCGGGATGGCTATCGATCTTGAGAG
CCCGCTTTCTGACGATGACGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3F4N7