116113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 279966..280687 Replicon plasmid pCFSAN047154_1
Accession NZ_CP034475
Organism Pantoea agglomerans strain CFSAN047154

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D1629_RS20475 Protein ID WP_033773376.1
Coordinates 279966..280277 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D1629_RS20480 Protein ID WP_010247064.1
Coordinates 280274..280687 (+) Length 138 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1629_RS20465 276669..277961 - 1293 WP_010247061.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -
D1629_RS20470 277972..279525 - 1554 WP_129063350.1 aspartate aminotransferase family protein -
D1629_RS20475 279966..280277 + 312 WP_033773376.1 type II toxin-antitoxin system HigB family toxin Toxin
D1629_RS20480 280274..280687 + 414 WP_010247064.1 helix-turn-helix domain-containing protein Antitoxin
D1629_RS20485 280803..282176 - 1374 WP_033773374.1 PTS ascorbate transporter subunit IIC -
D1629_RS20490 282216..282488 - 273 WP_010247066.1 PTS sugar transporter subunit IIB -
D1629_RS20495 282537..282986 - 450 WP_033773372.1 PTS sugar transporter subunit IIA -
D1629_RS20500 283563..284297 + 735 WP_010247068.1 GntR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..613013 613013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12138.01 Da        Isoelectric Point: 9.6067

>T116113 WP_033773376.1 NZ_CP034475:279966-280277 [Pantoea agglomerans]
MHIISRGPFREAAIIYPNHASALDAAYLVLRDENFATPDALKISFQSLDRMKYREKWWVIDVGGNSLRIMFYADFDRGKI
FIKHIVTHAEYDKLVKKYRESKE

Download         Length: 312 bp

>T116113 NZ_CP034475:279966-280277 [Pantoea agglomerans]
ATGCATATCATCTCAAGAGGGCCGTTCAGGGAAGCGGCAATAATTTATCCAAATCATGCCTCCGCACTGGATGCGGCTTA
TCTGGTCCTAAGGGACGAAAACTTTGCCACGCCAGATGCGCTGAAAATTAGCTTTCAGAGCCTTGACCGCATGAAGTACC
GGGAAAAGTGGTGGGTAATCGATGTGGGCGGAAACAGCCTGAGAATCATGTTTTATGCTGACTTTGATCGCGGCAAAATT
TTTATCAAACACATCGTGACGCATGCGGAATATGACAAGCTGGTGAAGAAGTACCGGGAGAGTAAAGAATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15402.41 Da        Isoelectric Point: 4.9795

>AT116113 WP_010247064.1 NZ_CP034475:280274-280687 [Pantoea agglomerans]
MITEAIQATNDLVRIVPFLGGSTDKRDYEQALELVEYLVEHQPDSPLVEILSDKVARYENSAPEFAAFNARTDAIPRGVA
LLRVIMDQHGLTQSSFADEIGQRSYVSRILRGDRPLTDKHKARLAARFNLPFEAFAE

Download         Length: 414 bp

>AT116113 NZ_CP034475:280274-280687 [Pantoea agglomerans]
ATGATTACCGAAGCAATCCAGGCGACCAATGACCTGGTCAGAATTGTTCCCTTTCTGGGAGGCAGTACCGATAAAAGGGA
CTACGAGCAGGCGCTGGAACTGGTTGAATATCTGGTTGAGCACCAGCCGGACAGCCCGTTAGTAGAGATACTGTCTGATA
AAGTCGCCCGATACGAAAACAGCGCCCCTGAGTTCGCTGCGTTTAACGCGCGTACTGATGCTATTCCGCGCGGAGTAGCA
CTTTTGCGAGTCATCATGGATCAGCACGGCCTGACTCAATCCTCTTTTGCGGATGAAATAGGGCAGCGCTCTTATGTCAG
TCGTATCCTGCGTGGTGATCGTCCTTTGACGGATAAACATAAAGCCCGACTGGCAGCGCGTTTTAACCTGCCGTTTGAAG
CATTCGCTGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References