Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 279966..280687 | Replicon | plasmid pCFSAN047154_1 |
Accession | NZ_CP034475 | ||
Organism | Pantoea agglomerans strain CFSAN047154 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | D1629_RS20475 | Protein ID | WP_033773376.1 |
Coordinates | 279966..280277 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | D1629_RS20480 | Protein ID | WP_010247064.1 |
Coordinates | 280274..280687 (+) | Length | 138 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D1629_RS20465 | 276669..277961 | - | 1293 | WP_010247061.1 | lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein | - |
D1629_RS20470 | 277972..279525 | - | 1554 | WP_129063350.1 | aspartate aminotransferase family protein | - |
D1629_RS20475 | 279966..280277 | + | 312 | WP_033773376.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
D1629_RS20480 | 280274..280687 | + | 414 | WP_010247064.1 | helix-turn-helix domain-containing protein | Antitoxin |
D1629_RS20485 | 280803..282176 | - | 1374 | WP_033773374.1 | PTS ascorbate transporter subunit IIC | - |
D1629_RS20490 | 282216..282488 | - | 273 | WP_010247066.1 | PTS sugar transporter subunit IIB | - |
D1629_RS20495 | 282537..282986 | - | 450 | WP_033773372.1 | PTS sugar transporter subunit IIA | - |
D1629_RS20500 | 283563..284297 | + | 735 | WP_010247068.1 | GntR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | iroN | 1..613013 | 613013 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12138.01 Da Isoelectric Point: 9.6067
>T116113 WP_033773376.1 NZ_CP034475:279966-280277 [Pantoea agglomerans]
MHIISRGPFREAAIIYPNHASALDAAYLVLRDENFATPDALKISFQSLDRMKYREKWWVIDVGGNSLRIMFYADFDRGKI
FIKHIVTHAEYDKLVKKYRESKE
MHIISRGPFREAAIIYPNHASALDAAYLVLRDENFATPDALKISFQSLDRMKYREKWWVIDVGGNSLRIMFYADFDRGKI
FIKHIVTHAEYDKLVKKYRESKE
Download Length: 312 bp
>T116113 NZ_CP034475:279966-280277 [Pantoea agglomerans]
ATGCATATCATCTCAAGAGGGCCGTTCAGGGAAGCGGCAATAATTTATCCAAATCATGCCTCCGCACTGGATGCGGCTTA
TCTGGTCCTAAGGGACGAAAACTTTGCCACGCCAGATGCGCTGAAAATTAGCTTTCAGAGCCTTGACCGCATGAAGTACC
GGGAAAAGTGGTGGGTAATCGATGTGGGCGGAAACAGCCTGAGAATCATGTTTTATGCTGACTTTGATCGCGGCAAAATT
TTTATCAAACACATCGTGACGCATGCGGAATATGACAAGCTGGTGAAGAAGTACCGGGAGAGTAAAGAATGA
ATGCATATCATCTCAAGAGGGCCGTTCAGGGAAGCGGCAATAATTTATCCAAATCATGCCTCCGCACTGGATGCGGCTTA
TCTGGTCCTAAGGGACGAAAACTTTGCCACGCCAGATGCGCTGAAAATTAGCTTTCAGAGCCTTGACCGCATGAAGTACC
GGGAAAAGTGGTGGGTAATCGATGTGGGCGGAAACAGCCTGAGAATCATGTTTTATGCTGACTTTGATCGCGGCAAAATT
TTTATCAAACACATCGTGACGCATGCGGAATATGACAAGCTGGTGAAGAAGTACCGGGAGAGTAAAGAATGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15402.41 Da Isoelectric Point: 4.9795
>AT116113 WP_010247064.1 NZ_CP034475:280274-280687 [Pantoea agglomerans]
MITEAIQATNDLVRIVPFLGGSTDKRDYEQALELVEYLVEHQPDSPLVEILSDKVARYENSAPEFAAFNARTDAIPRGVA
LLRVIMDQHGLTQSSFADEIGQRSYVSRILRGDRPLTDKHKARLAARFNLPFEAFAE
MITEAIQATNDLVRIVPFLGGSTDKRDYEQALELVEYLVEHQPDSPLVEILSDKVARYENSAPEFAAFNARTDAIPRGVA
LLRVIMDQHGLTQSSFADEIGQRSYVSRILRGDRPLTDKHKARLAARFNLPFEAFAE
Download Length: 414 bp
>AT116113 NZ_CP034475:280274-280687 [Pantoea agglomerans]
ATGATTACCGAAGCAATCCAGGCGACCAATGACCTGGTCAGAATTGTTCCCTTTCTGGGAGGCAGTACCGATAAAAGGGA
CTACGAGCAGGCGCTGGAACTGGTTGAATATCTGGTTGAGCACCAGCCGGACAGCCCGTTAGTAGAGATACTGTCTGATA
AAGTCGCCCGATACGAAAACAGCGCCCCTGAGTTCGCTGCGTTTAACGCGCGTACTGATGCTATTCCGCGCGGAGTAGCA
CTTTTGCGAGTCATCATGGATCAGCACGGCCTGACTCAATCCTCTTTTGCGGATGAAATAGGGCAGCGCTCTTATGTCAG
TCGTATCCTGCGTGGTGATCGTCCTTTGACGGATAAACATAAAGCCCGACTGGCAGCGCGTTTTAACCTGCCGTTTGAAG
CATTCGCTGAATAA
ATGATTACCGAAGCAATCCAGGCGACCAATGACCTGGTCAGAATTGTTCCCTTTCTGGGAGGCAGTACCGATAAAAGGGA
CTACGAGCAGGCGCTGGAACTGGTTGAATATCTGGTTGAGCACCAGCCGGACAGCCCGTTAGTAGAGATACTGTCTGATA
AAGTCGCCCGATACGAAAACAGCGCCCCTGAGTTCGCTGCGTTTAACGCGCGTACTGATGCTATTCCGCGCGGAGTAGCA
CTTTTGCGAGTCATCATGGATCAGCACGGCCTGACTCAATCCTCTTTTGCGGATGAAATAGGGCAGCGCTCTTATGTCAG
TCGTATCCTGCGTGGTGATCGTCCTTTGACGGATAAACATAAAGCCCGACTGGCAGCGCGTTTTAACCTGCCGTTTGAAG
CATTCGCTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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