Detailed information of TA system TA116106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 130457..131109
• Replicon: chromosome
• Accession: NZ_CP034474
• Organism: Pantoea agglomerans strain CFSAN047154

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8X8DRT2
• Locus tag: D1629_RS00590
• Protein ID: WP_010672045.1
• Coordinates: 130756..131109 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8X8DRN0
• Locus tag: D1629_RS00585
• Protein ID: WP_010252120.1
• Coordinates: 130457..130756 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1629_RS00565	126401..127366	-	966	WP_033770846.1	AraC family transcriptional regulator	-
D1629_RS00570	127471..128658	+	1188	WP_010252123.1	MFS transporter	-
D1629_RS00575	128871..129080	+	210	WP_009092571.1	DUF1471 domain-containing protein	-
D1629_RS00580	129282..130334	+	1053	WP_033770847.1	YncE family protein	-
D1629_RS00585	130457..130756	-	300	WP_010252120.1	XRE family transcriptional regulator	Antitoxin
D1629_RS00590	130756..131109	-	354	WP_010672045.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1629_RS00595	131344..132585	-	1242	WP_033770848.1	peptide antibiotic transporter SbmA	-
D1629_RS00600	132862..133596	+	735	WP_010672043.1	gluconate 2-dehydrogenase subunit 3 family protein	-
D1629_RS00605	133599..135383	+	1785	WP_129062731.1	GMC family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13660.67 Da
• Isoelectric Point: 7.9792

>T116106 WP_010672045.1 NZ_CP034474:c131109-130756 [Pantoea agglomerans]
MWTVLLSPRFESWLSEQEEALQEKMLADLGKLKVYGPDLPRPYADTLKGSQYRNMKELRVQFSGKPIRAFYAFDPVRQAI
VLCAGDKSHDKRFYIRMIRIADDEFSAWLAEQEKGNN

Nucleotide

• Length: 354 bp

>T116106 NZ_CP034474:c131109-130756 [Pantoea agglomerans]
ATGTGGACCGTACTCCTGAGCCCGCGCTTTGAAAGCTGGCTAAGTGAGCAGGAAGAAGCCCTGCAGGAAAAAATGTTAGC
GGATCTGGGAAAGTTAAAAGTATACGGCCCTGATTTGCCTCGCCCTTATGCTGATACTCTCAAGGGCTCGCAGTACAGGA
ATATGAAAGAACTCCGCGTACAGTTTTCAGGAAAGCCAATTCGGGCATTTTATGCATTTGACCCTGTCCGCCAGGCTATT
GTGTTATGTGCCGGAGATAAGAGTCATGACAAACGTTTTTATATCCGAATGATACGCATCGCTGACGATGAATTTTCAGC
CTGGCTGGCTGAACAGGAGAAGGGAAATAATTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11116.99 Da
• Isoelectric Point: 6.3781

>AT116106 WP_010252120.1 NZ_CP034474:c130756-130457 [Pantoea agglomerans]
MRTLDDVIADFSPESQARIKKMSDEMILEVGLQMIREELQLSQKTLAEAMGVRQPAVAQIEQRGNEIKVATLKRYVEAMG
GKLSLDVELPTGKRVAFRI

Nucleotide

• Length: 300 bp

>AT116106 NZ_CP034474:c130756-130457 [Pantoea agglomerans]
ATGAGAACCCTGGATGATGTTATCGCCGACTTCTCCCCTGAGAGTCAGGCGCGAATCAAAAAAATGTCTGATGAAATGAT
TCTGGAAGTCGGGCTTCAGATGATTCGCGAAGAGCTTCAGTTATCACAAAAGACGCTCGCCGAGGCCATGGGCGTGCGTC
AGCCTGCCGTTGCTCAGATTGAGCAACGCGGAAATGAGATTAAGGTTGCCACGCTGAAACGCTATGTCGAAGCAATGGGC
GGAAAACTCAGTCTTGATGTGGAACTTCCGACCGGAAAAAGAGTGGCCTTTCGCATCTGA