Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 130457..131109 Replicon chromosome
Accession NZ_CP034474
Organism Pantoea agglomerans strain CFSAN047154

Toxin (Protein)


Gene name higB Uniprot ID A0A8X8DRT2
Locus tag D1629_RS00590 Protein ID WP_010672045.1
Coordinates 130756..131109 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8X8DRN0
Locus tag D1629_RS00585 Protein ID WP_010252120.1
Coordinates 130457..130756 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1629_RS00565 126401..127366 - 966 WP_033770846.1 AraC family transcriptional regulator -
D1629_RS00570 127471..128658 + 1188 WP_010252123.1 MFS transporter -
D1629_RS00575 128871..129080 + 210 WP_009092571.1 DUF1471 domain-containing protein -
D1629_RS00580 129282..130334 + 1053 WP_033770847.1 YncE family protein -
D1629_RS00585 130457..130756 - 300 WP_010252120.1 XRE family transcriptional regulator Antitoxin
D1629_RS00590 130756..131109 - 354 WP_010672045.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1629_RS00595 131344..132585 - 1242 WP_033770848.1 peptide antibiotic transporter SbmA -
D1629_RS00600 132862..133596 + 735 WP_010672043.1 gluconate 2-dehydrogenase subunit 3 family protein -
D1629_RS00605 133599..135383 + 1785 WP_129062731.1 GMC family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13660.67 Da        Isoelectric Point: 7.9792

>T116106 WP_010672045.1 NZ_CP034474:c131109-130756 [Pantoea agglomerans]
MWTVLLSPRFESWLSEQEEALQEKMLADLGKLKVYGPDLPRPYADTLKGSQYRNMKELRVQFSGKPIRAFYAFDPVRQAI
VLCAGDKSHDKRFYIRMIRIADDEFSAWLAEQEKGNN

Download         Length: 354 bp

>T116106 NZ_CP034474:c131109-130756 [Pantoea agglomerans]
ATGTGGACCGTACTCCTGAGCCCGCGCTTTGAAAGCTGGCTAAGTGAGCAGGAAGAAGCCCTGCAGGAAAAAATGTTAGC
GGATCTGGGAAAGTTAAAAGTATACGGCCCTGATTTGCCTCGCCCTTATGCTGATACTCTCAAGGGCTCGCAGTACAGGA
ATATGAAAGAACTCCGCGTACAGTTTTCAGGAAAGCCAATTCGGGCATTTTATGCATTTGACCCTGTCCGCCAGGCTATT
GTGTTATGTGCCGGAGATAAGAGTCATGACAAACGTTTTTATATCCGAATGATACGCATCGCTGACGATGAATTTTCAGC
CTGGCTGGCTGAACAGGAGAAGGGAAATAATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11116.99 Da        Isoelectric Point: 6.3781

>AT116106 WP_010252120.1 NZ_CP034474:c130756-130457 [Pantoea agglomerans]
MRTLDDVIADFSPESQARIKKMSDEMILEVGLQMIREELQLSQKTLAEAMGVRQPAVAQIEQRGNEIKVATLKRYVEAMG
GKLSLDVELPTGKRVAFRI

Download         Length: 300 bp

>AT116106 NZ_CP034474:c130756-130457 [Pantoea agglomerans]
ATGAGAACCCTGGATGATGTTATCGCCGACTTCTCCCCTGAGAGTCAGGCGCGAATCAAAAAAATGTCTGATGAAATGAT
TCTGGAAGTCGGGCTTCAGATGATTCGCGAAGAGCTTCAGTTATCACAAAAGACGCTCGCCGAGGCCATGGGCGTGCGTC
AGCCTGCCGTTGCTCAGATTGAGCAACGCGGAAATGAGATTAAGGTTGCCACGCTGAAACGCTATGTCGAAGCAATGGGC
GGAAAACTCAGTCTTGATGTGGAACTTCCGACCGGAAAAAGAGTGGCCTTTCGCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References