Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 526090..526811 Replicon plasmid pCFSAN047153_1
Accession NZ_CP034470
Organism Pantoea agglomerans strain CFSAN047153

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D1628_RS21680 Protein ID WP_033773376.1
Coordinates 526500..526811 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D1628_RS21675 Protein ID WP_010247064.1
Coordinates 526090..526503 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1628_RS21655 522480..523214 - 735 WP_010247068.1 GntR family transcriptional regulator -
D1628_RS21660 523791..524240 + 450 WP_033773372.1 PTS sugar transporter subunit IIA -
D1628_RS21665 524289..524561 + 273 WP_010247066.1 PTS sugar transporter subunit IIB -
D1628_RS21670 524601..525974 + 1374 WP_033773374.1 PTS ascorbate transporter subunit IIC -
D1628_RS21675 526090..526503 - 414 WP_010247064.1 helix-turn-helix domain-containing protein Antitoxin
D1628_RS21680 526500..526811 - 312 WP_033773376.1 type II toxin-antitoxin system HigB family toxin Toxin
D1628_RS21685 527252..528805 + 1554 WP_129063350.1 aspartate aminotransferase family protein -
D1628_RS21690 528816..530108 + 1293 WP_010247061.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..613013 613013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12138.01 Da        Isoelectric Point: 9.6067

>T116103 WP_033773376.1 NZ_CP034470:c526811-526500 [Pantoea agglomerans]
MHIISRGPFREAAIIYPNHASALDAAYLVLRDENFATPDALKISFQSLDRMKYREKWWVIDVGGNSLRIMFYADFDRGKI
FIKHIVTHAEYDKLVKKYRESKE

Download         Length: 312 bp

>T116103 NZ_CP034470:c526811-526500 [Pantoea agglomerans]
ATGCATATCATCTCAAGAGGGCCGTTCAGGGAAGCGGCAATAATTTATCCAAATCATGCCTCCGCACTGGATGCGGCTTA
TCTGGTCCTAAGGGACGAAAACTTTGCCACGCCAGATGCGCTGAAAATTAGCTTTCAGAGCCTTGACCGCATGAAGTACC
GGGAAAAGTGGTGGGTAATCGATGTGGGCGGAAACAGCCTGAGAATCATGTTTTATGCTGACTTTGATCGCGGCAAAATT
TTTATCAAACACATCGTGACGCATGCGGAATATGACAAGCTGGTGAAGAAGTACCGGGAGAGTAAAGAATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15402.41 Da        Isoelectric Point: 4.9795

>AT116103 WP_010247064.1 NZ_CP034470:c526503-526090 [Pantoea agglomerans]
MITEAIQATNDLVRIVPFLGGSTDKRDYEQALELVEYLVEHQPDSPLVEILSDKVARYENSAPEFAAFNARTDAIPRGVA
LLRVIMDQHGLTQSSFADEIGQRSYVSRILRGDRPLTDKHKARLAARFNLPFEAFAE

Download         Length: 414 bp

>AT116103 NZ_CP034470:c526503-526090 [Pantoea agglomerans]
ATGATTACCGAAGCAATCCAGGCGACCAATGACCTGGTCAGAATTGTTCCCTTTCTGGGAGGCAGTACCGATAAAAGGGA
CTACGAGCAGGCGCTGGAACTGGTTGAATATCTGGTTGAGCACCAGCCGGACAGCCCGTTAGTAGAGATACTGTCTGATA
AAGTCGCCCGATACGAAAACAGCGCCCCTGAGTTCGCTGCGTTTAACGCGCGTACTGATGCTATTCCGCGCGGAGTAGCA
CTTTTGCGAGTCATCATGGATCAGCACGGCCTGACTCAATCCTCTTTTGCGGATGAAATAGGGCAGCGCTCTTATGTCAG
TCGTATCCTGCGTGGTGATCGTCCTTTGACGGATAAACATAAAGCCCGACTGGCAGCGCGTTTTAACCTGCCGTTTGAAG
CATTCGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References