Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2239373..2239985 Replicon chromosome
Accession NZ_CP034447
Organism Mesorhizobium sp. M1E.F.Ca.ET.045.02.1.1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EJ070_RS10815 Protein ID WP_126091352.1
Coordinates 2239373..2239669 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EJ070_RS10820 Protein ID WP_126091353.1
Coordinates 2239677..2239985 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ070_RS10785 2234676..2235527 + 852 WP_126091347.1 5-dehydro-4-deoxy-D-glucuronate isomerase -
EJ070_RS10790 2235524..2236291 + 768 WP_126091348.1 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD -
EJ070_RS10795 2236321..2236650 + 330 WP_126091349.1 cupin domain-containing protein -
EJ070_RS10800 2236889..2237635 + 747 WP_126095704.1 sulfotransferase -
EJ070_RS10805 2237632..2238591 + 960 WP_126091350.1 hypothetical protein -
EJ070_RS10810 2238620..2239246 - 627 WP_126091351.1 LysE family translocator -
EJ070_RS10815 2239373..2239669 + 297 WP_126091352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJ070_RS10820 2239677..2239985 + 309 WP_126091353.1 HigA family addiction module antidote protein Antitoxin
EJ070_RS10825 2240105..2241946 + 1842 WP_126091354.1 DNA helicase RecQ -
EJ070_RS10830 2242028..2242480 - 453 WP_126091355.1 cupin domain-containing protein -
EJ070_RS10835 2242477..2243106 - 630 WP_126091356.1 TetR/AcrR family transcriptional regulator -
EJ070_RS10840 2243514..2243768 + 255 WP_126091357.1 type II toxin-antitoxin system ParD family antitoxin -
EJ070_RS10845 2243768..2244055 + 288 WP_126091358.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11747.31 Da        Isoelectric Point: 8.6397

>T116072 WP_126091352.1 NZ_CP034447:2239373-2239669 [Mesorhizobium sp. M1E.F.Ca.ET.045.02.1.1]
MIAGFRDEWLRAFFVDDVRSRNIPPDLELRLFRKLQMIDDATTDLDLRVPPSNHFEKLRGNLEGFHSIRVNKQWRLVFRW
DGRRGEASGVYLDDHSYR

Download         Length: 297 bp

>T116072 NZ_CP034447:2239373-2239669 [Mesorhizobium sp. M1E.F.Ca.ET.045.02.1.1]
ATGATCGCTGGCTTTCGGGACGAGTGGTTGCGAGCCTTCTTCGTTGACGACGTGCGCTCAAGGAATATCCCGCCCGATCT
CGAACTGCGGCTGTTCCGCAAGCTCCAGATGATCGATGATGCGACGACCGATCTGGATTTGCGCGTGCCGCCCAGTAATC
ATTTCGAGAAATTGCGCGGCAACCTCGAAGGGTTCCATTCGATCCGCGTCAACAAGCAATGGCGGCTGGTATTCCGGTGG
GACGGTCGCCGCGGTGAAGCGTCGGGCGTCTATCTTGACGACCATAGCTACAGATAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11787.70 Da        Isoelectric Point: 11.5608

>AT116072 WP_126091353.1 NZ_CP034447:2239677-2239985 [Mesorhizobium sp. M1E.F.Ca.ET.045.02.1.1]
MLTTKRRPVRIGEILVEEFMRPMGLTQAALAEAMGVQRKHVNELCNNRRNVTAPTALILARVFGNSPEFWLNVQRRSDLW
EAMHNPKERERIERARPLPNAA

Download         Length: 309 bp

>AT116072 NZ_CP034447:2239677-2239985 [Mesorhizobium sp. M1E.F.Ca.ET.045.02.1.1]
ATGCTGACGACCAAGCGCAGACCGGTGAGGATCGGCGAGATCCTGGTGGAGGAGTTCATGCGGCCGATGGGTCTCACGCA
AGCCGCCTTGGCCGAGGCAATGGGCGTGCAACGCAAGCATGTCAATGAGCTCTGCAACAATCGTCGCAACGTCACGGCGC
CGACCGCGCTTATCCTTGCGCGTGTGTTCGGCAACAGCCCCGAGTTCTGGCTCAATGTGCAGCGGCGCAGTGATCTGTGG
GAGGCGATGCACAACCCGAAGGAGCGTGAGAGGATCGAGCGCGCGCGTCCGTTGCCGAACGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References