Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 705151..705764 Replicon chromosome
Accession NZ_CP034446
Organism Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EJ069_RS03320 Protein ID WP_126060071.1
Coordinates 705468..705764 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EJ069_RS03315 Protein ID WP_126060070.1
Coordinates 705151..705459 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ069_RS03295 700351..701250 + 900 WP_126064614.1 LysR family transcriptional regulator -
EJ069_RS03300 701305..702483 - 1179 WP_126060067.1 lytic murein transglycosylase -
EJ069_RS03305 702667..703455 - 789 WP_126060068.1 glycoside hydrolase family 25 protein -
EJ069_RS03310 703747..705129 + 1383 WP_126060069.1 serine hydrolase -
EJ069_RS03315 705151..705459 - 309 WP_126060070.1 HigA family addiction module antidote protein Antitoxin
EJ069_RS03320 705468..705764 - 297 WP_126060071.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJ069_RS03325 705869..706534 - 666 WP_126060072.1 class I SAM-dependent methyltransferase -
EJ069_RS03330 706531..707829 - 1299 WP_126060073.1 DUF3419 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-69)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11614.07 Da        Isoelectric Point: 7.3192

>T116066 WP_126060071.1 NZ_CP034446:c705764-705468 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
MIVGFRDGWLRTFFVDDIHSRNIPSDLESRLFRKLQMIDDAATDQDLRVPPSNHFEKLRGSLEGFRSIRVNKQWRLVFRW
DGGRGEASDIYLDDHSYK

Download         Length: 297 bp

>T116066 NZ_CP034446:c705764-705468 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
ATGATCGTTGGATTTAGAGATGGATGGCTGCGGACCTTCTTCGTGGATGATATCCACTCCCGCAACATTCCGTCCGATCT
CGAAAGCCGCTTGTTTCGCAAGCTCCAGATGATCGACGACGCTGCGACCGATCAGGATTTGCGCGTGCCGCCCAGCAATC
ATTTCGAAAAGTTGCGCGGCAGTCTCGAAGGCTTCCGTTCCATACGCGTCAACAAGCAATGGCGGTTGGTTTTCCGCTGG
GATGGCGGTCGGGGTGAGGCGTCGGACATCTACCTGGACGACCACAGCTATAAGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11394.16 Da        Isoelectric Point: 9.4075

>AT116066 WP_126060070.1 NZ_CP034446:c705459-705151 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
MLMTARKPATVGEILTEEFMHPLGLTQAALAEAMGVPRKHVNELCNDRRNVTAATALILARVFGNSPDFWLNVQRRNDLW
QVMNSPDERARVDRAKPLPTAA

Download         Length: 309 bp

>AT116066 NZ_CP034446:c705459-705151 [Mesorhizobium sp. M2A.F.Ca.ET.043.05.1.1]
ATGTTGATGACCGCACGCAAGCCGGCAACGGTTGGCGAAATTCTTACGGAAGAGTTCATGCACCCGCTCGGCTTGACGCA
AGCCGCTCTGGCCGAGGCAATGGGCGTCCCGCGCAAGCATGTGAACGAATTGTGCAACGATCGCCGCAACGTTACCGCAG
CGACCGCGCTCATATTGGCGCGGGTGTTCGGCAATAGCCCGGATTTCTGGCTGAATGTCCAACGCCGCAACGACCTTTGG
CAGGTCATGAACTCGCCTGACGAGCGGGCGCGTGTCGATCGTGCTAAGCCCTTGCCGACAGCCGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References